Prognostic significance of the Medical Research Council cytogenetic classification compared with the European LeukaemiaNet risk classification system in acute myeloid leukaemia |
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| Authors: | Tapan Kadia Hagop Kantarjian Guillermo Garcia‐Manero Gautam Borthakur Xuemei Wang Keyur Patel Elias Jabbour Mark Brandt Naval Daver Naveen Pemmaraju Sherry Pierce Jorge Cortes Farhad Ravandi |
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| Affiliation: | 1. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA |
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| Abstract: | Fibrosis has been reported in some patients with immune thrombocytopenia (ITP) treated with thrombopoietin receptor agonists (TPO‐RA). However, fibrosis has also been reported in patients with various stages of ITP, who were TPO‐RA treatment‐naïve. In our study, we looked for fibrosis in bone marrow trephine biopsies taken at initial diagnosis from 32 adult patients with ITP. Ten of the 32 evaluated samples (31·25%) showed increased reticulin (Grade 1–2 on Bauermeister scale and Grade 0–1 on the European Consensus scale), which showed a positive correlation with ethnicity (0·3%) but did not correlate with disease severity, any clinical features or co‐morbidities. |
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| Keywords: | acute myeloid leukaemia cytogenetics of leukaemia prognostic factors |
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