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Survival of AIDS‐related diffuse large B‐cell lymphoma,Burkitt lymphoma,and plasmablastic lymphoma in the German HIV Lymphoma Cohort |
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| Authors: | Christian Hoffmann Daniel Gillor Alexander Zoufaly Björn Jensen Johannes R. Bogner Jan Thoden Jan‐Christian Wasmuth Timo Wolf Mark Oette Markus Müller Stefan Esser Jörg J. Vehreschild Gerd Fätkenheuer Christoph Wyen |
| Affiliation: | 1. IPM Study Center, Hamburg and University of Schleswig Holstein, Campus Kiel, Hamburg, Germany;2. First Department of Internal Medicine, University of Cologne, Cologne, Germany;3. Department of Medicine I, University Medical Centre Hamburg‐Eppendorf, Hamburg, Germany;4. Department of Gastroenterology, Hepatology and Infectiology, University of Düsseldorf, Düsseldorf, Germany;5. Department of Internal Medicine IV, University of Munich, Munich, Germany;6. Private Practice of Rheumatology and Infectious Diseases, Freiburg, Germany;7. Department of Internal Medicine I, University of Bonn, Bonn, Germany;8. Department of Medicine III, University of Frankfurt, Frankfurt, Germany;9. Department of General Medicine, Gastroenterology and Infectious Diseases, Augustinerinnen Hospital, Cologne, Germany;10. Department of Infectious Diseases, Vivantes Auguste‐Viktoria‐Hospital, Berlin, Germany;11. Department of Dermatology, University of Essen, Essen, Germany;12. German Centre for Infection Research (DZIF), Cologne, Germany |
| Abstract: | Overall survival (OS) of patients with acquired immunodeficiency syndrome (AIDS)‐related Burkitt lymphoma (BL), diffuse large B‐cell lymphoma (DLBCL) and plasmablastic lymphoma (PBL) was analysed in the German AIDS‐related‐Lymphoma‐Cohort‐Study. Of 291 patients prospectively included between January 2005 and December 2012, 154 had DLBCL, 103 BL and 34 PBL. Two‐year OS rates were similar between BL (69%) and DLBCL patients (63%) but lower for PBL patients (43%). Intermediate (Hazard ratio [HR] 4·1 95% confidence interval [CI] 1·98–8·49) or high (HR 4·92 95% CI 2·1–11·61) International Prognostic Index, bone marrow involvement (HR 1·69 95% CI 1·00–2·84) and PBL histology (HR 2·24 95% CI 1·24–4·03) were independent predictors of mortality. |
| Keywords: | AIDS‐related lymphoma AIDS‐related Burkitt lymphoma AIDS‐related diffuse large B‐cell‐lymphoma AIDS‐related plasmablastic lymphoma lymphoma |