| 通络方防治大鼠肾小球硬化的作用机制 |
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| 引用本文： | 吴喜利,孙万森,张王刚,王竹. 通络方防治大鼠肾小球硬化的作用机制[J]. 南方医科大学学报, 2008, 28(7): 1198-1201 |
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| 作者姓名： | 吴喜利 孙万森 张王刚 王竹 |
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| 作者单位： | 西安交通大学医学院第二附属医院中西医结合科,陕西省中医重点专科肾病科,陕西,西安,710004;西安交通大学医学院第二附属医院血液科,陕西,西安,710004 |
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| 基金项目： | 陕西省中医药管理局资助项目 , 西安交通大学医学院第二附属医院青年基金 |
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| 摘 要： | 目的 观察通络方对肾组织中Ⅳ型胶原(Col Ⅳ)、纤维连接蛋白(FN)、层粘连蛋白(LN)及转化生长因子β1(TGF-β1)表达的影响,探讨通络方防治大鼠肾小球硬化的作用机制.方法 通过光镜观察治疗组肾脏病理学改变,同时应用免疫组化技术及网像采集分析系统测定各组大鼠肾脏组织中Ⅳ-C、FN、LN、TGF-β1表达情况.结果 通络方可明显降低大鼠肾组织中Col Ⅳ、FN、LN、TGF-β1表达(P<0.05或P<0.01),减轻肾脏的病理损害(P<0.01).结论 通络方可能是通过降低肾脏组织中Col Ⅳ、FN、LN及TGF-β1表达起到治疗作用的.
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| 关 键 词： | 通络方 肾小球硬化 转化生长因子β1 Ⅳ型胶原 纤维连接蛋白 层粘连蛋白 |
Mechanism of the effect of Tongluo Recipe against glomerular sclerosis in rats |
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| WU Xi-li,SUN Wan-sen,ZHANG Wang-gang,WANG Zhu. Mechanism of the effect of Tongluo Recipe against glomerular sclerosis in rats[J]. Journal of Southern Medical University, 2008, 28(7): 1198-1201 |
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| Authors: | WU Xi-li SUN Wan-sen ZHANG Wang-gang WANG Zhu |
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| Affiliation: | Department of Integrated Traditional Chinese and Western Medicine, Shaanxi Provincial Key TCM Department of Nephrology, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.E-mail.wuxili1984 @163.com. |
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| Abstract: | OBJECTIVE: To investigate the effects of Tongluo Recipe on the expression of collagen IV (Col IV), fibronectin (FN), laminin (LN), transforming growth factor-beta1 (TGF-beta1) in rat renal tissues and explore the mechanism underlying these effects in rats with glomerular sclerosis. METHODS: The pathological changes in the renal tissues of rats with glomerular sclerosis were observed microscopically, and the expressions of Col IV, FN, LN, and TGF-beta1 were detected using immunohistochemical staining and image analysis system. RESULTS: Tongluo Recipe significantly decreased the expressions of Col IV, FN, LN and TGF-beta1 in the renal tissue of rats with glomerular sclerosis (P<0.05 or P<0.01) and obviously alleviated the renal pathologies (P<0.01). CONCLUSION: The therapeutic effects of Tongluo Recipe are probably mediated by lowered expressions of Col IV, FN, LN and TGF-beta1. |
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