| 茶对吸烟致人外周血淋巴细胞DNA损伤的保护作用 |
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| 引用本文： | 崔文明, 张馨, 王伟, 李宁, 韩驰. 茶对吸烟致人外周血淋巴细胞DNA损伤的保护作用[J]. 中国公共卫生, 2002, 18(8): 944-945. DOI: 10.11847/zgggws2002-18-08-25 |
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| 作者姓名： | 崔文明 张馨 王伟 李宁 韩驰 |
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| 作者单位： | 1.中国预防医学科学院营养与食品卫生研究所 北京100050 |
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| 摘 要： | 目的 探讨饮茶对吸烟所致人体DNA损伤的保护作用,以及为确证茶与人类肿瘤的关系提供直接依据.方法 选择46名吸烟者作为研究对象,以外周血淋巴细胞微核发生率和染色体畸变率为生物学观察终点,进行混合茶对吸烟致外周血淋巴细胞DNA损伤影响的6个月的随机、双盲干预试验研究.结果 试验组每天服用3g混合茶6个月后,其外周血淋巴细胞微核发生率和染色体畸变率明显降低,而试验对照组试验前后基本无变化.结论 混合茶对吸烟致外周血淋巴细胞DNA损伤可能有保护作用,从而对人类癌症可能有预防作用.
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| 关 键 词： | 茶 吸烟 DNA损伤 |
| 文章编号： | 1001-0580(2002)08-0944-02 |
| 收稿时间： | 2002-02-25 |
| 修稿时间： | 2002-02-25 |
Study on Preventive Effect of Tea on DNA Damage of Lymphocytes in Human Induced by Cigarette Smoking |
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| CUI Wen-min, ZHANG Xin, WANG Wei, . Study on Preventive Effect of Tea on DNA Damage of Lymphocytes in Human Induced by Cigarette Smoking[J]. Chinese Journal of Public Health, 2002, 18(8): 944-945. DOI: 10.11847/zgggws2002-18-08-25 |
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| Authors: | CUI Wen-min ZHANG Xin WANG Wei |
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| Affiliation: | 1.Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine Beijing 100050, China |
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| Abstract: | Objective In order to study the preventive effect of tea on DNA damage induced by cigarette smoking and to provide evidence on the protective effects of tea in human cancer.Methods Based micronuclei frequency and chromosome aberrations frequency of peripheral bloodly mphocytes as end point,the effect of mixed tea on smoke-induced DNA damage was investigated in 46 smokers in a six month,double-blind and randomized placebo-controlled intervention trial.Results A kind of mixed tea given in an oral dose of 3g/day for 6 months,significantly decreased the micronucleii formation and chromosome aberrations frequency in lymphocytes.In contrast,there was no significant change in the micronuclei frequency and chromosome aberration frequency after 6 months in the placebo group.Conclusion The results indicated that mixed tea may reduce cancer risk by preventing DNA damage in human induced by cigarette smoking and have preventive effect on human cancer. |
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| Keywords: | tea smoking DNA damage |
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