Characterization of Fatty Acid Profiles in Infants With Intestinal Failure–Associated Liver Disease |
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| Authors: | Meredith A. Baker MD Paul D. Mitchell MSc Alison A. O'Loughlin MEd Alexis K. Potemkin BSN Lorenzo Anez‐Bustillos MD Duy T. Dao MD Gillian L. Fell MD PhD Kathleen M. Gura PharmD Mark Puder MD PhD |
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| Affiliation: | 1. Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Boston, Massachusetts, USA;2. Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA;3. Department of Pharmacy, Boston Children's Hospital, Boston, MA, USA |
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| Abstract: | Background The purpose of this study was to characterize fatty acid profiles (FAPs) in parenteral nutrition (PN)‐dependent infants with intestinal failure–associated liver disease (IFALD) receiving soybean oil–based lipid emulsion (SO) doses of ～3 and ～1 g/kg/d. Methods Prospectively collected data were retrospectively reviewed. Serum FAPs of patients <1 year old who experienced development of IFALD while receiving standard PN with SO were examined before transitioning to a fish oil–based lipid emulsion for IFALD treatment. Time on SO, dose, gestational age, and weight‐ and length‐for‐age z scores were also reviewed. Results Among the 49 patients analyzed, there were no differences in demographics or anthropometrics between patients who received standard SO (SO‐S) (n = 14, range of dosage 2.06–3.31 g/kg/d) and reduced SO (SO‐R) (n = 35, range of dosage 0.90–1.34 g/kg/d). Patients received SO for a median of 53 days (interquartile range 39, 73) before FAP measurement. Patients who received SO‐R had significantly higher Mead acid and lower α‐linolenic, eicosapentaenoic, linoleic, stearic, total ω‐3, and total ω‐6 fatty acid levels than patients who received SO‐S (P < .01). Triene:tetraene ratios were higher in patients who received SO‐R (P = .0009), and no patients experienced biochemical essential fatty acid deficiency (EFAD). Conclusion PN‐dependent infants with IFALD receiving SO‐R have different FAPs than patients receiving SO‐S. No patients in either group had biochemical EFAD. |
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| Keywords: | lipids nutrition parenteral nutrition nutrition fatty acids research and diseases pediatrics life cycle intestinal failure– associated liver disease intravenous lipid emulsion |
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