| 两种国产乙型肝炎疫苗预防接种效果分析 |
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| 引用本文： | 何岭,彭秀丽. 两种国产乙型肝炎疫苗预防接种效果分析[J]. 国际生物制品学杂志, 2010, 33(1): 14-15. DOI: 10.3760/cma.j.issn.1673-4211.2010.01.004 |
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| 作者姓名： | 何岭 彭秀丽 |
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| 作者单位： | 450052 郑州铁路疾病预防控制所免疫规划科 |
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| 摘 要： | 目的 了解郑州某高校新生对两种国产乙型肝炎（乙肝）疫苗预防接种的效果。方法 采用随机抽样方法，抽取743名新生分为两组，分别接种重组乙肝疫苗（CHO细胞）和重组乙肝疫苗（汉逊酵母），剂量均为10μg/0.5ml, 按0、1、6个月免疫程序接种，免疫后2个月，检测血清抗-HBs滴度，比较两种疫苗的抗体阳转率和几何平均浓度（GMC）。结果 重组乙肝疫苗（CHO细胞）组的抗体阳转率为87.14%，重组乙肝疫苗（汉逊酵母）组的抗体阳转率为97.20%。两组疫苗的抗-HBs GMC分别为1489.72和2265.68 mIU/ml。 结论 国产重组乙肝疫苗（汉逊酵母）预防接种效果良好，应大力 推广使用。
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| 关 键 词： | 乙型肝炎疫苗 接种 人群监测 |
Analysis of immunization effects of two kinds of domestic hepatitis B vaccines |
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| Affiliation: | EPI Department, Zhengzhou Railway Center for Disease Control and Prevention. Zhengzhou 450052,China |
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| Abstract: | Objective To evaluate immunization effects of two kinds of domestic recombinant hepatitis B vaccines in college freshmen.Methods A total of 743 freshmen were randomly divided into recombinant hepatitis B vaccine (CHO cell) group and recombinant hepatitis B vaccine (Hansenula polymorpha) group,and the freshmen in each group were immunized with 3 doses of the corresponding vaccine 10μg/0.5 ml at a schedule of 0, 1, and 6 months.Serum anti-HBs titer was measured 2 months after the last vaccination, and antibody positive rates and geometric mean concentration (GMC) were compared between the two groups.χ~2 test was adopted in the comparison between the two groups.ResultsAntibody positive rates were 87.14% in recombinant hepatitis B vaccine (CHO cell) group and 97.20% in recombinant hepatitis B vaccine (Hansenula polymorpha) group, and there was a statistically significant difference between the two groups(χ~2 = 6.28,P ＜ 0.05).Anti-HBs GMCs were 1489.72 and 2265.68 IU/L, respectively, in the two groups.Conclusion The effect of recombinant hepatitis B vaccine (Hansenula polymorpha) is good, which can be used widely. |
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| Keywords: | Hepatitis B vaccine Vaccination Population surveillance |
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