Contribution of Candida albicans ALS1 to the pathogenesis of experimental oropharyngeal candidiasis |
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| Authors: | Kamai Yasuki Kubota Mikie Kamai Yoko Hosokawa Tsunemichi Fukuoka Takashi Filler Scott G |
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| Affiliation: | Biological Research Laboratory, Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan. ykamai@shina.sankyo.co.jp |
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| Abstract: | We investigated the contribution of Candida albicans ALS1, which encodes a candidal adhesin, to the pathogenesis of experimental murine oropharyngeal candidiasis. Our results indicate that the ALS1 gene product is important for the adherence of the organism to the oral mucosa during the early stage of the infection. |
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