| 影像引导下125I粒子植入治疗肺癌的疗效分析 |
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| 引用本文： | 胡丽丽,李小东,张雪宁,牛冬梅,杨景奎,时代,王琳,苏倩. 影像引导下125I粒子植入治疗肺癌的疗效分析[J]. 国际放射医学核医学杂志, 2013, 37(4): 203-206. DOI: 10.3760/cma.j.issn.1673-4114.2013.04.004 |
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| 作者姓名： | 胡丽丽 李小东 张雪宁 牛冬梅 杨景奎 时代 王琳 苏倩 |
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| 作者单位： | 1.300074，天津市儿童医院放射科 |
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| 摘 要： | 目的 探讨CT引导下经皮穿刺125I粒子植入治疗晚期肺癌的可行性、疗效及并发症情况。 方法 根据治疗方法的不同，将65例晚期肺癌患者分为2组，单纯植入粒子组37例，行单纯CT引导下125I粒子植入治疗；联合组28例，行125I粒子植入治疗联合泽菲和顺铂化疗，两组患者术后均行剂量学验证，并定期随访复查。 结果 65例患者术后总有效率为80.0%，1年生存率为90.8%，单纯植入粒子组与联合组的有效率分别为67.6%和96.4%，两组之间差异有统计学意义（χ2=8.298，P < 0.01）。所有患者治疗前肿瘤平均直径为5.48 cm，治疗后为3.77 cm，治疗前、后差异有统计学意义（t=7.764，P < 0.01）。65例患者术后36例出现气胸，7例出现血痰，4例出现发热，对症处理后均好转；未出现放射性肺炎等。 结论 125I粒子植入治疗晚期肺癌的近期疗效肯定，无严重并发症。
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| 关 键 词： | 肺肿瘤 碘放射性同位素 近距离放射疗法 体层摄影术，X线计算机 |
| 收稿时间： | 2013-04-24 |
Efficacy of CT guided radioactive 125I seed implantation in the treatment of lung cancer |
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| Li-li HU,Xiao-dong LI,Xue-ning ZHANG,Dong-mei NIU,Jing-kui YANG,Dai SHI,Lin WANG,Qian SU. Efficacy of CT guided radioactive 125I seed implantation in the treatment of lung cancer[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2013, 37(4): 203-206. DOI: 10.3760/cma.j.issn.1673-4114.2013.04.004 |
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| Authors: | Li-li HU Xiao-dong LI Xue-ning ZHANG Dong-mei NIU Jing-kui YANG Dai SHI Lin WANG Qian SU |
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| Affiliation: | 1.Department of Radiology, Tianjin Children′s Hospital, Tianjin 300074, China |
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| Abstract: | Objective To investigate the feasibility, efficacy and complications of CT guided radio-active 125I seed implantation in the treatment of lung cancer. Methods According to the different treatment methods, 65 patients with lung cancer were divided into two groups, 37 cases in the implantation alone group received CT guided 125I seeds interstitial implantation, the other 28 cases in the combination treatment group received interstitial 125I seeds implantation combined with chemotherapy. All the patients were examined by posologic validation, and were followed up termly. Results The total effictive rate of 65 patients was 80.0%, 1-year survival rate was 90.8%. The effictive rates of implantation alone group and combination treatment group were 67.6% and 96.4% respectively. There was a significant difference between the two groups(χ2=8.298, P < 0.01). Before treatment, all the patients′ mean diameter of the tumor was 5.48 cm; while it was 3.77 cm after treatment(t=7.764, P < 0.01). Complications included pneumothorax(36 cases), bloody sputum(7 cases), fever (4 cases) which improved after treatment in 65 patients, but without radiation pneumonia. Conclusion 125I seed implantation is a highly effective treatment without severe complications in the treatment of lung cancer. |
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