| 高血压病患者眼底病变分级与眼血流动力学参数的相关性 |
| |
| 引用本文： | 李成武 庄曾渊 刘静 安娜 朱永涛. 高血压病患者眼底病变分级与眼血流动力学参数的相关性[J]. 眼科, 2017, 26(3): 206. DOI: 10.13281/j.cnki.issn.1004-4469.2017.03.013 |
| |
| 作者姓名： | 李成武 庄曾渊 刘静 安娜 朱永涛 |
| |
| 作者单位： | 100102.北京，中国中医科学院望京医院（李成武、刘静、安娜、朱永涛）；100040 北京，中国中医科学院眼科医院（庄曾渊） |
| |
| 基金项目： | 国家中医药管理局庄曾渊全国名老中医药专家传承工作室建设项目(2013年)； 中国中医科学院“名医名家传承”项目(CM2014GD1033)；中国中医科学院望京医院科研课题（WJYY2016-PY-041） |
| |
| 摘 要： | 目的 探讨高血压病患者眼底病变分级与眼血流动力学参数的关系。设计 病例对照研究。研究对象 中国中医科学院望京医院内科住院的无糖尿病和高脂血症且视网膜动脉硬化Ⅱ级及以上的高血压病患者120例（240眼）。方法 充分散瞳下应用TOPCON眼底照相机采集120例患者双眼彩色眼底像，并按照Keith-Wagener法进行高血压性视网膜病变分级，按照Scheie法进行视网膜动脉硬化分级，采用彩色多普勒超声测量眼动脉（OA）和视网膜中央动脉（CRA）血流动力学参数，比较不同级别眼底病变眼血流动力学参数之间的差异。主要指标 OA和CRA血流动力学参数: 收缩期峰值血流速度（PSV）、舒张末期血流速度（EDV）、平均血流速度（MFV）、搏动指数（PI）、阻力指数（RI）、收缩期与舒张末期血流速度比（S/D=PSV/EDV）。结果 高血压性视网膜病变Ⅱ级和Ⅲ级及以上者OA的EDV、PI、RI以及S/D分别为（10.14±2.13）cm/s和（8.06±0.26）cm/s（t=-8.64，P=0.001）、1.28±0.21和1.56±0.24（t=24.6，P=0.001）、0.69±0.12和0.75±0.12（t=68.4，P=0.001）、3.22±0.87和4.18±1.14（t=18.9，P=0.001）。高血压性视网膜病变Ⅱ级和Ⅲ级及以上者CRA的EDV、PI、RI以及S/D分别为（3.73±0.39）cm/s和（3.18±0.44）cm/s（t=-23.41，P=0.000）、1.07±0.08和1.28±0.10（t=18.7，P=0.001）、0.62±0.02和0.68±0.04（t=17.32，P=0.000）、2.66±0.41和2.99±0.27（t=35.6，P=0.002）。视网膜动脉硬化Ⅱ、Ⅲ、Ⅳ级者OA的EDV、PI、RI以及S/D分别为（10.30±2.27）cm/s、（8.90±0.93）cm/s、（7.74±0.74）cm/s（F=7.509，P=0.003）；1.23±0.22、1.40±0.24、1.58±0.38（F=36.214，P=0.003）；0.68±0.01、0.72±0.02、0.77±0.01（F=121.615，P=0.000）；3.08±0.67、3.61±1.01、4.32±1.65（F=28.514，P=0.003）。视网膜动脉硬化Ⅱ、Ⅲ、Ⅳ级者CRA的EDV、PI、RI以及S/D分别为（3.78±0.33）cm/s、（3.47±0.28）cm/s、（2.91±0.27）cm/s（F=-22.377，P=0.000）； 1.04±0.06、1.16±0.13、1.38±0.12（F=17.619，P=0.003）；0.61±0.02、0.65±0.06、0.72±0.02（F=24.156，P=0.000）；2.58±0.31、2.89±0.40、3.55±0.41（F=15.424，P=0.000）。结论 高血压病患者眼底病变分级与眼血流动力学参数之间有相关性，随着视网膜病变加重，眼动脉和视网膜中央动脉舒张末期血流速度减小、搏动指数增大、阻力指数增大。
|
| 关 键 词： | 高血压性视网膜病变 视网膜动脉硬化 血流动力学参数 |
| 收稿时间： | 2016-02-09 |
Correlation between ocular fundus lesion grading and ocular hemodynamics in patients with essential hypertension |
| |
| LI Cheng-wu,ZHUANG Zeng-yuan,LIU Jing,AN Na,ZHU Yong-tao. Correlation between ocular fundus lesion grading and ocular hemodynamics in patients with essential hypertension[J]. Ophthalmology in China, 2017, 26(3): 206. DOI: 10.13281/j.cnki.issn.1004-4469.2017.03.013 |
| |
| Authors: | LI Cheng-wu ZHUANG Zeng-yuan LIU Jing AN Na ZHU Yong-tao |
| |
| Affiliation: | 1. Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China; 2. Eye Hospital of China Academy of Chinese Medical Sciences, Beijing 100040, China |
| |
| Abstract: | Objective To investigate the relationship between ocular fundus lesion grading and ocular hemodynamics parameters in hypertensive patients. Design Case-control study. Participants A total of 120 medical hospitalized hypertensive patients in Wangjing Hospital. Methods The fundus color photographys of the both eyes of the 120 patients were collected using the TOPCON fundus camera in the pupil fully dispersed. The hypertensive retinopathy was graded according to the Keith-Wagener method. The retinal arteriosclerosis grade was performed according to the Scheie method. Hemodynamic parameters of ophthalmic artery (OA) and central retinal artery(CRA) were measured by color Doppler ultrasound. The differences of hemodynamics parameters, including peak systolic velocity (PSV), end-diastolic velocity(EDV), medial flow velocity (MFV), pulsatility index(PI), drag index (RI) of the OA and the CRA were compared between different grades. S/D=PSV/EDV. Main Outcome Measures The hemodynamic parameters, including PSV, EDV, MFV, PI, RI, S/D of the OA and the CRA. Results The EDV, PI, RI and S/D of the OA of the patients with hypertensive retinopathy level Ⅱ, level Ⅲ and above were (10.14±2.13) cm/s and (8.06±0.26) cm/s (t=-8.64，P=0.001), 1.28±0.21 and 1.56±0.24 (t=24.6，P=0.001), 0.69±0.12 and 0.75±0.12 (t=68.4，P=0.001), 3.22±0.87 and 4.18±1.14 (t=18.9，P=0.001). The EDV, PI, RI and S/D of the CRA of the patients with hypertensive retinopathy level Ⅱ, level Ⅲ and above were (3.73±0.39) cm/s and (3.18±0.44) cm/s (t=-23.41, P=0.000), 1.07±0.08 and 1.28±0.10 (t=18.7, P=0.001), 0.62±0.02 and 0.68±0.04 (t=17.32, P=0.000), 2.66±0.41 and 2.99±0.27 (t=35.6, P=0.002). The EDV, PI, RI and S/D of the OA of the patients with retinal arteriosclerosis level Ⅱ, level Ⅲ and level Ⅳ were (10.30±2.27) cm/s, (8.90±0.93)cm/s, (7.74±0.74) cm/s (F=7.509，P=0.003)；1.23±0.22, 1.40±0.24, 1.58±0.38 (F=36.214，P=0.003)；0.68±0.01, 0.72±0.02, 0.77±0.01 (F=121.615，P=0.000)；3.08±0.67, 3.61±1.01, 4.32±1.65(F=28.514，P=0.003). The EDV, PI, RI and S/D of the CRA of the patients with retinal arteriosclerosis level Ⅱ, level Ⅲ and level Ⅳ were (3.78±0.33) cm/s, (3.47±0.28) cm/s, (2.91±0.27) cm/s(F=-22.377, P=0.000)；1.04±0.06, 1.16±0.13, 1.38±0.12(F=17.619，P=0.003)；0.61±0.02, 0.65±0.06, 0.72±0.02(F=24.156，P=0.000); 2.58±0.31, 2.89±0.40, 3.55±0.41 (F=15.424，P=0.000). Conclusion There was a correlation between ocular fundus lesion grading and ocular hemodynamics in hypertensive patients. With the increasing of retinopathy grading, the velocity of end-diastolic blood flow in the ophthalmic artery and central retinal artery decreased, the pulsatility index increased and the resistance index increased. |
| |
| Keywords: | hypertensive retinopathy retinal arteriosclerosis hemodynamic parameters |
|
| 点击此处可从《眼科》浏览原始摘要信息 |
|
点击此处可从《眼科》下载免费的PDF全文 |
|
