Animal models of coronary heart disease |
| |
| Authors: | Jiawei Liao Wei Huang George Liu |
| |
| Affiliation: | Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education,Peking University Health Science Center, Beijing, 100191, China |
| |
| Abstract: | Cardiovascular disease, predominantly coronary heart disease and stroke, leads to high morbidity and mortality not only in developed worlds but also in underdeveloped regions. The dominant pathologic foundation for cardiovascular disease is atherosclerosis and, as to coronary heart disease, coronary atherosclerosis and resulting lumen stenosis, even total occlusions. In translational research, several animals, such as mice, rabbits and pigs, have been used as disease models of human atherosclerosis and related cardiovascular disorders. However, coronary lesions are either naturally rare or hard to be fast induced in these models, hence, coronary heart disease induction mostlyrelies on surgical or pharmaceutical interventions with no or limited primary coronary lesions, thus unrepresentative of human coronary heart disease progression and pathology. In this review, we describe the progress of animal models of coronary heart disease following either spontaneous or diet accelerated coronary lesions. |
| |
| Keywords: | coronary heart disease animal models coronary atherosclerosis coronary arteriosclerosis |
|
| 点击此处可从《生物医学研究杂志》浏览原始摘要信息 |
|
点击此处可从《生物医学研究杂志》下载免费的PDF全文 |
|
