| 羊膜腔穿刺对母婴HBV垂直传播的meta分析 |
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| 引用本文： | 李桃源, 何京, 卢永平, 梁旭竞, HOCHERBerthold, 陈友鹏. 羊膜腔穿刺对母婴HBV垂直传播的meta分析[J]. 分子影像学杂志, 2017, 40(3): 299-303. doi: 10.3969/j.issn.1674-4500.2017.03.14 |
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| 作者姓名： | 李桃源 何京 卢永平 梁旭竞 HOCHERBerthold 陈友鹏 |
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| 作者单位： | 1.暨南大学附属第一医院感染科，广东 广州 510630;;2.Department of Nephrology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin Germany;;3.Department of Experimental Nutritional Medicine, Institute for Nutritional Science, University of Potsdam, Potsdam 14558, Germany |
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| 摘 要： | 目的母婴乙肝病毒垂直传播已成为我国乙肝病毒感染的主要途径，本研究分析乙肝病毒感染的孕妇进行羊膜腔穿刺是否增加母婴垂直传播的风险。方法搜索1990年1月1日~2016年3月15日之间在Pubmed、Embase、谷歌学术和万方数据库等数据库中所有关于乙肝孕妇行羊膜腔穿刺对母婴垂直传播影响的相关英文或中文文章，根据纳入剔除标准对文章进行筛选，然后对文章治疗评分，最后有4篇文章纳入，共有3997孕妇，其中实验组167名、对照组3830名，使用Review Manager Version 5.0进行数据分析。结果荟萃分析结果显示，进行羊膜腔穿刺术与不行羊膜腔穿刺术两组婴儿HBsAg阳性率无明显差异（R2=1.37，95% CI: 0.70~2.69，P=0.36）。当孕妇是HBV-DNA≥107 copies/mL、HBeAg阳性时，进行羊膜腔穿刺术后胎儿宫内感染风险增加（R2=9.54，95% CI: 3.52~25.85，P<0.0004；R2=3.41，95% CI: 1.05~11.13，P=0.04）。结论孕妇HBV-DNA≥107 copy/mL和（或）HBeAg阳性时将增加母婴垂直传播的风险。
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| 关 键 词： | 羊水穿刺 母婴垂直传播 慢性乙型肝炎 乙型肝炎病毒 荟萃分析 |
| 收稿时间： | 2017-04-27 |
Meta analysis of mother-to-child transmission of HBV by amniocentesis |
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| Taoyuan LI, Jing HE, Yongping LU, Xujing LIANG, Berthold HOCHER, Youpeng CHEN. Meta analysis of mother-to-child transmission of HBV by amniocentesis[J]. Journal of Molecular Imaging, 2017, 40(3): 299-303. doi: 10.3969/j.issn.1674-4500.2017.03.14 |
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| Authors: | Taoyuan LI Jing HE Yongping LU Xujing LIANG Berthold HOCHER Youpeng CHEN |
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| Affiliation: | 1. Department of Infectious Diseases, the first Affiliated Hospital of Jinan University, Guangzhou 510630, China;;2. Department of Nephrology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin Germany;;3. Department of Experimental Nutritional Medicine, Institute for Nutritional Science, University of Potsdam, Potsdam 14558, Germany |
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| Abstract: | ObjectiveTo explore if amniocentesis in pregnant with HBV infection carriers will increase the risk of mother-to-child transmission(MTCT).MethodsAll relevant published papers and abstracts of English and Chinese were searched by the key words such as hepatitis B virus/HBV, amniocentesis, vertical/mother-to-child transmission in Pubmed (MEDLINE), Embase, Google scholar and Wanfang database between January 1 1990 and March 15 2016. Four papers with 3997 pregnant women including 167 amniocentesis cases and 3830 control cases were entered to this analysis. The analysis was performed by statistical software Review Manager Version 5.0.ResultsThe meta-analysis showed that there was no significant difference of infant’s HBsAg-positive rate between two groups of mothers who underwent amniocentesis or no amniocentesis (R2=1.37, 95% CI: 0.70~2.69, P=0.36). It increased the risk of MCTC of HBV if amniocentesis was performed in pregnant women with serum HBV-DNA≥107 copies/mL (R2=9.54, 95% CI: 3.52~25.85, P<0.0004) and/or HBeAg-positivity (R2=3.41, 95% CI: 1.05~11.13, P=0.04).ConclusionAmniocentesis in pregnant women with serum HBV-DNA ≥107 copies/mL and/or HBeAg-positivity would increase the risk of MTCT in HBV infection. |
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| Keywords: | amniocentesis mother to child transmission chronic hepatitis B HBV meta-analysis |
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