| 肝纤维化进程中细胞外基质对肝星状细胞的作用及机制研究进展* |
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| 引用本文： | 秦雨萌,陈胜华. 肝纤维化进程中细胞外基质对肝星状细胞的作用及机制研究进展*[J]. 实用肝脏病杂志, 2017, 20(3): 381-384. DOI: 10.3969/j.issn.1672-5069.2017.03.037 |
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| 作者姓名： | 秦雨萌 陈胜华 |
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| 作者单位： | 421001 湖南省衡阳市 南华大学医学院解剖学教研室 |
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| 基金项目： | *南华大学“蒸湘学者”计划资助项目（编号：2016ZXXZ006）; 湖南省研究生创新课题（编号：CX2016B476） |
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| 摘 要： | 肝纤维化是一种肝内弥漫性细胞外基质（ECM）过度沉积的病理过程,且肝星状细胞（HSC）的激活是肝纤维化发生发展的中心环节。本文主要介绍了在肝纤维化进程中ECM各种成分比例、分子结构的改变及其ECM分子空间结构改变对HSC的激活、增殖和凋亡的作用和机制。
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| 关 键 词： | 肝纤维化 细胞外基质 肝星状细胞 |
| 收稿时间： | 2016-11-10 |
Influence of extracellular matrix on hepatic stellate cells during liver fibrosis process |
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| Qin Yumeng,Chen Shenghua. Influence of extracellular matrix on hepatic stellate cells during liver fibrosis process[J]. Journal of Clinical Hepatology, 2017, 20(3): 381-384. DOI: 10.3969/j.issn.1672-5069.2017.03.037 |
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| Authors: | Qin Yumeng Chen Shenghua |
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| Affiliation: | Deparment of Anatomy, University of South China,Hengyang 421001,Hunan Province |
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| Abstract: | Liver fibrosis is a pathological process characterized by intrahepatic diffuse excess deposition of extracellular matrix（ECM）,and hepatic stellate cells （HSC） activation. This article mainly reviewed the changes of various components of ECM,the molecular structure and the spatial structure of the ECM in the process of hepatic fibrosis. And we also summarized the mechanism by which the effects of these changes on the activation,proliferation and apoptosis of HSCs. |
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| Keywords: | Liver fibrosis Extracellular matrix Hepatic stellate cell |
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