Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin |
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| Authors: | Parikh Sunil Liu Jun Sijwali Puran Gut Jiri Goldberg Daniel E Rosenthal Philip J |
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| Affiliation: | Department of Medicine, San Francisco General Hospital, University of California, San Francisco, 94110, USA. sparikh@medsfgh.ucsf.edu |
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| Abstract: | Human immunodeficiency virus type 1 protease inhibitors (HIVPIs) and pepstatin are aspartic protease inhibitors with antimalarial activity. In contrast to pepstatin, HIVPIs were not synergistic with a cysteine protease inhibitor or more active against parasites with the cysteine protease falcipain-2 knocked out than against wild-type parasites. As with pepstatin, HIVPIs were equally active against wild-type parasites and against parasites with the food vacuole plasmepsin aspartic proteases knocked out. The antimalarial mechanism of HIVPIs differs from that of pepstatin. |
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