| 日本血吸虫病患者尿液中循环抗原和抗体联合检测的诊断价值 |
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| 引用本文： | 张恩英,娄文娴,薛纯良,王兆军. 日本血吸虫病患者尿液中循环抗原和抗体联合检测的诊断价值[J]. 中国寄生虫学与寄生虫病杂志, 2000, 18(1): 24-25 |
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| 作者姓名： | 张恩英 娄文娴 薛纯良 王兆军 |
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| 作者单位： | 上海第二医科大学寄生虫学教研室,200025 |
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| 基金项目： | “九.五”国家重点基金资助课题(No 04-02-02)、国家自然科学基金资助课题(No 39510644)和上海市科委自然科学基金资助课题(No 954119010) |
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| 摘 要： | [目的 ]探讨尿液中血吸虫循环抗原和抗体检测对日本血吸虫病的诊断价值。 [方法 ]用单克隆抗体夹心 ELISA法检测日本血吸虫病患者尿液中循环抗原 ,间接ELISA检测尿液中特异性抗体。 [结果 ]10例急性血吸虫病和 6 1例慢性血吸虫病患者尿液中循环抗原的阳性率分别为 6 0 %和 40 % ,特异性抗体的阳性率分别为 80 %和 6 1 7%。两者联合检测的总阳性率分别为 10 0 %和 71 7%。 10 0例健康对照者尿液中仅 3%出现假阳性。 [结论 ]检测尿液中日本血吸虫循环抗原和特异性抗体简便、实用 ,为一种非损伤性的血吸虫病诊断方法。
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| 关 键 词： | 日本血吸虫病 循环抗原 特异性抗体 |
| 文章编号： | 1000-7423(2000)-01-0024-02 |
| 修稿时间： | 1999-03-01 |
THE DIAGNOSTIC VALUE OF COMBINED DETECTION OF CIRCULATING ANTIGENS AND ANTIBODIES IN URINE OF PATIENTS WITH SCHISTOSOMIASIS JAPONICA |
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| ZHANG En-ying,LOU Wen-xian,XUE Chun-liang,WANG Zhao-jun. THE DIAGNOSTIC VALUE OF COMBINED DETECTION OF CIRCULATING ANTIGENS AND ANTIBODIES IN URINE OF PATIENTS WITH SCHISTOSOMIASIS JAPONICA[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2000, 18(1): 24-25 |
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| Authors: | ZHANG En-ying LOU Wen-xian XUE Chun-liang WANG Zhao-jun |
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| Affiliation: | ZHANG En-ying,LOU Wen-xian,XUE Chun-liang,WANG Zhao-jun(Department of Parasitology,Shanghai Second Medicaal University,Shanghai 200025) |
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| Abstract: | Objective] To assess the value of detecting circulating antigens and antibodies in urine as a noninvasive method for the diagnosis of schistosomiasis. [Methods] A sandwich ELISA and ELISA using McAb were applied to detect circulating schistosomal antigens and specific antibodies in the urine of patients with acute and chronic schistosomiasis. [Results] When the urine samples from 10 cases of acute schistosomiasis and 61 cases of chronic schistosomiasis were examined, the positive rates of circulating antigens and specific antibodies were 60%,40%, and 80%, 60 1%, respectively; when both detection was combined, the positive rates were 100% and 71 7% respectively, whereas a false positive rate of 3% of CAg or CAb was detected in the urine of 100 normal controls. [Conclusion] The detection of circulating antigen in urine is a practicable and noninvasive method for the diagnosis of schistosomiasis. |
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| Keywords: | Schistosomiasis japonica circulating antigen specific antibody. |
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