| Effect of Ligustrazine on Kanamycin Ototoxicity |
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| 引用本文： | Wan-dong She,Zhao-he Chen. Effect of Ligustrazine on Kanamycin Ototoxicity[J]. 中国结合医学杂志, 1997, 3(3): 179-182. DOI: 10.1007/BF02935132 |
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| 作者姓名： | Wan-dong She Zhao-he Chen |
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| 作者单位： | SHE Wan-dong and CHEN Zhao-he (Department of Otolaryngology，Affiliated Drum Tower Hospital，Medical College of Nanjing University，Nanjing (210008)) |
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| 摘 要： | Ｅｆｆｅｃｔ ｏｆ Ｌｉｇｕｓｔｒａｚｉｎｅ ｏｎ Ｋａｎａｍｙｃｉｎ ＯｔｏｔｏｘｉｃｉｔｙＳＨＥＷａｎ－ｄｏｎｇ（佘万东）ａｎｄＣＨＥＮＺｈａｏ－ｈｅ（陈兆和）（ＤｅｐａｒｔｍｅｎｔｏｆＯｔｏｌａｒｙｎｇｏｌｏｇｙ，ＡｆｆｉｌｉａｔｅｄＤｒｕｍＴ...
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Effect of ligustrazine on kanamycin ototoxicity |
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| Wan-dong She and Zhao-he Chen. Effect of ligustrazine on kanamycin ototoxicity[J]. Chinese journal of integrative medicine, 1997, 3(3): 179-182. DOI: 10.1007/BF02935132 |
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| Authors: | Wan-dong She and Zhao-he Chen |
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| Affiliation: | 1. Department of Otolaryngology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, 210008, Nanjing
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| Abstract: | Objective: To evaluate the effect of ligustrazine on kanamycin ototoxicity. Methods: By measuring superoxide dismutase (SOD) and malondialdehyde (MDA) in cochlear tissues, compound action potentials (CAP) and cochlear microphonics (CM) in guinea-pigs which were treated with kanamycin and ligustrazine. Results : Kanamycin produced a severe hearing loss and significant increase in SOD and MDA. Ligustrazine could reduce these changes significantly and improve hearing of animals. Conclusion: Lipid peroxidativereaction is correlated with kanamycin ototoxicity and ligustrazine could prevent and treat kanamycin ototoxicity by antioxidation. |
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| Keywords: | Iigustrazine kanamycin ototoxicity cochlea superoxide dismutase malondialdehyde |
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