Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. |
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| Authors: | F Rousset E Garcia T Defrance C Péronne N Vezzio D H Hsu R Kastelein K W Moore J Banchereau |
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| Affiliation: | Schering-Plough, Laboratory for Immunological Research, Dardilly, France. |
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| Abstract: | Interleukin 10 (IL-10), originally identified as a TH2 helper T-cell product able to inhibit cytokine production by TH1 cells, is highly homologous to BCRF1 (viral IL-10), an open reading frame in the Epstein-Barr virus genome. Here, we show that human and viral IL-10 stimulate DNA replication of B lymphocytes activated either via their antigen receptor or via their CD40 antigen. IL-4 and IL-10 display additive effects and induce a strong increase in the number of viable cells. Moreover, IL-10 induces activated B cells to secrete large amounts of IgG, IgA, and IgM, and the combination of IL-10 and IL-4 results in the secretion of the four immunoglobulin isotypes. Thus, IL-10 may play an important role in the amplification of humoral responses. |
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