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Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple,NRAS and BRAF mutation‐negative nodules |
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| Authors: | Daniel de la Rosa Carrillo MD PhD Harald Vindenes MD Veronica A. Kinsler MD PhD Arild Rønnestad MD PhD Geir Ringstad MD Lil‐Sofie Ording Müller MD PhD Svetlana Tafjord MD Kim A. Tønseth MD PhD Bjørn Kvamme MD Ole Petter Fraas Clausen MD PhD |
| Affiliation: | 1. Department of Dermatology, Oslo University Hospital, Oslo, Norway;2. Faculty of Medicine, University of Oslo, Oslo, Norway;3. Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway;4. Paediatric Dermatology Department, Great Ormond Street Hospital, London, UK;5. Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway;6. Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway;7. Unit for Pediatric Radiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway;8. Department of Pathology, Oslo University Hospital, Oslo, Norway;9. Department of Dermatology, Neurology and Rheumatology, University Hospital of North Norway, Troms?, Norway |
| Abstract: | We report the case of a newborn boy with multinodular NRAS and BRAF mutation‐negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5 months of age. This case may represent an infantile melanoma developing from a giant congenital melanocytic nevus or a congenital melanoma. |
| Keywords: | neoplasms‐malignant nevi‐melanocytic |