| 高胆固醇血症患者白介素-6、白介素-10及肿瘤坏死因子α含量的变化及意义 |
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| 引用本文： | 刘时武,丁世芳,蒋桔泉,卢青. 高胆固醇血症患者白介素-6、白介素-10及肿瘤坏死因子α含量的变化及意义[J]. 实用医学杂志, 2008, 24(12): 2089-2091 |
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| 作者姓名： | 刘时武 丁世芳 蒋桔泉 卢青 |
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| 作者单位： | 广州军区武汉总医院心内科,430070 |
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| 摘 要： | ［摘要］ 目的：探讨高胆固醇血症患者白介素-6（IL-6）、白介素-10(IL-10)及肿瘤坏死因子α(TNF-α)的变化及意义。方法：入选高胆固醇血症患者72例，同时选取健康志愿者30例作为正常对照组。测定两组总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、IL-6、IL-10及TNF-α。结果：与健康对照组相比，高胆固醇血症患者TC、TG、LDL-C、IL-6、及TNF-α显著升高（p＜0.01），而IL-10显著降低（p＜0.01），HDL-C变化不明显。在高胆固醇血症患者中，IL-6与TC正相关（r=0.422，p=0.017）；TNF-α分别与TC（r=0.512，p=0.006）和TG 正相关(r=0.257，p=0.029 ）；IL-10分别与TC（r=－0.249，p=0.035）和TG负相关(r=－0.402，p=0.027）。结论：高胆固醇血症患者IL-6及TNF-α显著升高，而IL-10显著降低，高胆固醇血症患者存在慢性炎症反应过程。提高血清IL-10浓度，可能是治疗高胆固醇血症和动脉粥样硬化一条有效途径。
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| 关 键 词： | 高胆固醇血症 白介素-6 白介素-10 肿瘤坏死因子-α |
| 收稿时间： | 2008-02-28 |
The Changes of the Serum Interleukin-6 , Interleukin-10 and Tumor necrosis factor-α and Its Significance in Patients with Hypercholesterolemia. |
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| Abstract: | ［Abstract］ Objective: To observe the changes of the serum Interleukin-6 , Interleukin-10 and Tumor necrosis factor-αand its Significance in Patients with hypercholesterolemia. Methods The study group comprised 72 patients with hypercholesterolemia. the control group comprised 30 healthy volunteers. Serum levels of total cholesterol(TC), triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C), interleukin-6(IL-6) , interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) were measured in hypercholesterolemic patients and healthy volunteers . Results The serum levels of TC、TG、LDL-C、 IL-6 and TNF-αin hypercholesterolemia group were significantly higher than those in the control group（ all p＜0.01）, however the serum level of IL-10 was significantly lower than that in the control group（p＜0.01）. In hypercholesterolemia group,IL-6 showed a positive correlation with TC（r=0.422，p=0.017）；TNF-αshowed a positive correlation with TC (r=0.512，p=0.006) and TG (r=0.257，p=0.029); IL-10 showed a negative correlation with TC (r=－0.249，p=0.035) and TG (r=－0.402，p=0.027). Conclusions: Hypercholesterolemic patients are characterized by increased serum concentrations of IL-6 and TNF-α, by decreased significantly serum concentrations of IL-10. Hypercholesterolemia may be a chronic inflammation. Therapeutic strategies increasing IL-10 production may reduce the extent or severity of atherosclerosis and hypercholesterolemia. |
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