| 糖尿病性视网膜病变患者血清中脂肪细胞因子的表达及其影响因素分析 |
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| 引用本文： | 李莹莹,蔺晓慧. 糖尿病性视网膜病变患者血清中脂肪细胞因子的表达及其影响因素分析[J]. 眼科新进展, 2021, 0(1): 057-61. DOI: 10.13389/j.cnki.rao.2021.0012 |
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| 作者姓名： | 李莹莹 蔺晓慧 |
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| 作者单位： | 010000 内蒙古呼和浩特市，内蒙古自治区人民医院眼科 |
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| 基金项目： | 内蒙古自治区自然科学基金面上项目(编号2019MS08084)。 |
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| 摘 要： | 目的 研究糖尿病性视网膜病变（DR）患者血清中脂肪细胞因子Apelin及Omentin-1的变化，及其与临床指标间的相关性，探讨Omentin-1及Apelin在DR发生发展中所起的作用，以期用于糖尿病高危人群的筛选、预测、早期诊断。方法 收集2018年11月至2019年11月就诊于我院的2型糖尿病患者，其中合并DR者为DR组，未合并DR(NDR)者为NDR组，同期在我院眼科行白内障手术治疗者及门诊健康体检者作为正常对照组（NC组）。抽取空腹静脉血，分离血清。收集患者体质量指数（BMI）、糖化血红蛋白（HbA1c）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）、空腹胰岛素（FINS）、空腹血浆葡萄糖（FPG）、超敏CRP（hs-CRP)、胰岛素抵抗指数（HOMA-IR)及TyG指数等临床相关指标；采用ELISA检测血清中Apelin及Omentin-1蛋白浓度。结果 血清中，Apelin蛋白浓度DR组为（57.22±11.28）×10-3 ng?L-1，高于NDR组的（47.00±12.19 ）×10-3 ng?L-1，两组均高于NC组的（29.47±8.89）×10-3 ng?L-1；Omentin-1蛋白浓度DR组为（42.36±7.43）×10-3 ng?L-1，低于NDR组的（52.96±10.69）×10-3 ng?L-1，两组均低于NC组的（62.41±8.87）×10-3 ng?L-1，差异均有统计学意义(均为P<0.05)。血清Apelin水平与糖尿病严重程度、BMI、FPG、HOMA-IR、HbA1c、hs-CRP、TyG指数均呈正相关（均为P<0.05）；血清Omentin-1水平与DM严重程度、病程、BMI、FPG、HOMA-IR、HbA1c、hs-CRP、TyG指数、Apelin均呈负相关（均为P<0.05）。血清Omentin-1的ROC曲线下面积（0.771）大于血清Apelin的ROC曲线下面积（0.739），两者联合诊断时ROC曲线下面积为0.791。结论 Apelin、Omentin-1可能参与DR的发生发展；Apelin、Omentin-1可能在糖脂代谢、胰岛素抵抗方面发挥作用；血清Apelin、Omentin-1可能对是否发生DR起到一定的预测作用。
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| 关 键 词： | 糖尿病性视网膜病变 Apelin Omentin-1 糖尿病 脂肪因子 |
Expression of adipocytokines in the serum of patients with diabetic retinopathy and its factors |
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| LI Yingying,LIN Xiaohui. Expression of adipocytokines in the serum of patients with diabetic retinopathy and its factors[J]. Recent Advances in Ophthalmology, 2021, 0(1): 057-61. DOI: 10.13389/j.cnki.rao.2021.0012 |
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| Authors: | LI Yingying LIN Xiaohui |
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| Affiliation: | Department of Ophthalmology,People’s Hospital of Inner Mongolia Autonomous Region,Huhhot 010000,Inner Mongolia Autonomous Region,China |
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| Abstract: | Objective To study the changes of serum Apelin and Omentin-1 in patients with diabetic retinopathy,and their correlation with clinical indicators,to explore the role of Omentin-1 and Apelin in the development and development of DR for the high-risk population of diabetes’screening,prediction,and early diagnosis.Methods The patients with type 2 diabetes who were admitted to our hospital from November 2018 to November 2019 were collected.Among them,those with DR were in the DR group,and those without DR(non-DR,NDR)were in the NDR group.During the same period,those who underwent cataract surgery in the ophthalmology department of our hospital and those who had physical examination in the outpatient clinic served as the normal control group(NC group).Fasting venous blood was drawn for separating serum.The indicators including body mass index(BMI),glycated hemoglobin(HbA1c),high density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),Triglycerides(TG),fasting insulin(FINS),fasting plasma glucose(FPG),hypersensitivity CRP(Oy-CRP)and related insulin resistance index(HG-IRP)were collected.ELISA was used to detect the protein concentration of Apelin and Omentin-1 in serum.Results In the serum,the Apellin protein concentration in the DR group was(57.22±11.28)×10-3 ng·L-1,which was higher than that of the NDR group(47.00±12.19)×10-3 ng·L-1,and both groups were higher than the NC group(29.47±8.89)×10-3 ng·L-1.The Omintin-1 protein concentration in the DR group was(42.36±7.43)×10-3 ng·L-1,which was lower than the NDR group(52.96±10.69)×10-3 ng·L-1,and both groups was lower than the NC group(62.41±8.87)×10-3 ng·L-1,and the differences were statistically significant(all P<0.05).Serum Apelin level was positively correlated with diabetes severity,BMI,FPG,HOMA-IR,HbA1c,hs-CRP,and TyG index(all P<0.05);serum Omintin-1 level was correlated with DM severity,course of disease,BMI,FPGA,HO-MA-IR,HbA1c,hs-CRP,TyG index,and Apelin were all negatively correlated(all P<0.05).The area under the curve of serum Omentin-1(0.771)was greater than the area under the curve of serum Apelin(0.739),and the area under the curve for the combined diagnosis with serum Omentin-1 and Apelin was 0.791.Conclusion Apelin and Omentin-1 may be involved in the occurrence and development of DR;Apelin and Omentin-1 may play a role in glucose and lipid metabolism and insulin resistance;serum Apelin and Omentin-1 may play a certain role in predicting the occurrence of DR. |
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| Keywords: | diabetic retinopathy Apelin Omentin-1 diabetes adipokine |
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