| 外周T细胞淋巴瘤和NK/T细胞淋巴瘤指南的更新解读 |
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| 引用本文： | 高天晓,李志铭. 外周T细胞淋巴瘤和NK/T细胞淋巴瘤指南的更新解读[J]. 中国肿瘤临床, 2020, 47(20): 1039-1043. DOI: 10.3969/j.issn.1000-8179.2020.20.117 |
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| 作者姓名： | 高天晓 李志铭 |
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| 作者单位： | 中山大学肿瘤防治中心肿瘤内科(广州市 510080) |
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| 摘 要： | 外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)是来源于胸腺后不同阶段的生物学行为及临床表现具有明显异质性的一类恶性淋巴肿瘤。诊断时多为晚期且进展迅速,即使接受高强度的治疗,治愈率仍较低。结外NK/T细胞淋巴瘤(extranodal NK/T-cell lymphoma,ENKTL)为原发于鼻腔或其他结外器官的NK/T细胞淋巴瘤,属于结外非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)的一种少见特殊类型,占NHL的5%～15%。其发病具有明显的地域和种族差异性,亚洲人群相对高发。ENKTL恶性程度高、临床进展快且预后差。寻求更为标准化、规范化的诊疗指导,学习并理解国际及国内的权威指南尤为重要。本文将对中国临床肿瘤学会(CSCO)淋巴瘤指南以及美国肿瘤学临床实践(NCCN)指南等进行解读,重点对近两年(2019年至2020年)指南中PTCL及自然杀伤T细胞淋巴瘤(natural killer T-cell lymphoma,NKTCL)的部分更改和新增内容进行总结。
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| 关 键 词： | 淋巴瘤 指南 外周T细胞淋巴瘤 结外NK/T细胞淋巴瘤 治疗 |
| 收稿时间： | 2020-09-07 |
Updated interpretation of guidelines for peripheral T-cell and NK/T-cell lymphoma |
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| Affiliation: | Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510080, China |
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| Abstract: | Peripheral T-cell lymphoma (PTCL) is a type of malignant lymphoma that is derived from different stages of T-cell carcinogenesis in the posterior thymus and has obvious heterogeneity in biological behavior and clinical manifestations. Diagnosis of PTCL is mostly during late stage and progresses rapidly. Even with high-intensity treatment, the cure rate is still low. Extranodal NK/T cell lymphoma (ENKTL) is defined as NK/T cell lymphoma that originates in the nasal cavity or other extranodal organs. ENKTL is a rare and special type with highly relative incidence in Asian populations, accounting for about 5%-15% of NHL. ENKTCL has a high degree of malignancy, rapid clinical progress, and poor prognosis. In order to seek more standardized diagnosis and treatment guidance, it is particularly important to learn and understand authoritative guidelines international and domestic. In this passage, we will interpret clinical guidelines such as the Chinese Society of Clinical Oncology (CSCO) lymphoma guidelines and the National Comprehensive Cancer Network (NCCN) guidelines, focusing on the changes in the PTCL and NKTCL guidelines in the past two years (2019-2020). |
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