| 内皮功能障碍在心力衰竭中的作用 |
| |
| 引用本文： | 方瑾,黄鹤. 内皮功能障碍在心力衰竭中的作用[J]. 心脏杂志, 2021, 33(2): 195-198. DOI: 10.12125/j.chj.202011015 |
| |
| 作者姓名： | 方瑾 黄鹤 |
| |
| 作者单位： | 武汉大学人民医院心血管内科 心血管病湖北省重点实验室，湖北 武汉 430060 |
| |
| 基金项目： | 国家重点研发计划项目资助（2017YFC1700504） |
| |
| 摘 要： | 在心力衰竭的病理生理学中，内皮功能障碍的作用尚不完全清楚。氧化应激引起的内皮功能障碍会诱发心力衰竭。内皮功能和一氧化氮（NO）-环磷酸鸟苷(cGMP)途径参与心力衰竭的病理生理过程。内皮依赖性的血管舒张改变引起反复的缺血/再灌注，可诱发心肌的收缩与舒张功能障碍，NO-cGMP通路的改变直接影响心肌稳态。内皮功能障碍与心力衰竭更差的预后密切相关，与心血管事件更高的发生率密切相关。心力衰竭患者NO-cGMP途径提供了潜在的治疗策略基础，尽管目前相关临床数据尚无明确定论，但NO-cGMP途径是一个有希望的潜在治疗靶标。本文将对内皮功能障碍的病理生理机制、在心衰发生发展中的作用以及在心衰治疗的潜在价值进行综述。
|
| 关 键 词： | 心力衰竭 内皮功能障碍 一氧化氮 |
| 收稿时间： | 2020-11-08 |
Role of endothelial dysfunction in heart failure |
| |
| Affiliation: | Department of Cardiology & Hubei Key Laboratory of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei, China |
| |
| Abstract: | The role of endothelial dysfunction in the pathophysiology of heart failure is not yet clear. Endothelial dysfunction, induced by oxidative stress, contributes to the development of heart failure. Alterations of endothelial function and nitric oxide-cyclicguanosine monophosphate (NO-cGMP) pathway are involved in the pathophysiology of heart failure with both reduced and preserved ejection fraction. Indeed, an altered endothelium dependent vasodilatation, causing repeated episodes of ischemia/reperfusion, can induce a chronic stunned myocardium with systolic dysfunction and an increased diastolic stiffness with diastolic dysfunction. Moreover, the altered NO-cGMP pathway directly affects myocardial homeostasis. Endothelial dysfunction is associated with worse prognosis and higher rate of cardiovascular events. Potential therapeutic strategies targeting the NO-cGMP pathway in patients with heart failure will be discussed in this article. Although clinical data are still inconclusive, the NO-cGMP pathway represents a promising target for therapy. |
| |
| Keywords: | |
|
| 点击此处可从《心脏杂志》浏览原始摘要信息 |
|
点击此处可从《心脏杂志》下载全文 |
|
