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Investigating the heterogeneity of alkylating agents’ efficacy and toxicity between sexes: A systematic review and meta‐analysis of randomized trials comparing cyclophosphamide and ifosfamide (MAIAGE study)
Authors:Brice Fresneau  A. Hackshaw  D.S. Hawkins  M. Paulussen  J.R. Anderson  I. Judson  S. Litière  U. Dirksen  I. Lewis  H. van den Berg  N. Gaspar  H. Gelderblom  J. Whelan  A.V. Boddy  K. Wheatley  J.P. Pignon  F. De Vathaire  M.C. Le Deley  G. Le Teuff
Affiliation:1. Department of Pediatric oncology, Gustave Roussy, Université Paris‐Saclay, Villejuif, France;2. Cancer Research UK & UCL Cancer Trials Centre, University College London, London, United Kingdom;3. Division of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington;4. Vestische Kinder‐und Jugendklinik Datteln, Witten/Herdecke University, Datteln, Germany;5. Merck Research Laboratories—Oncology, North Wales, Pennsylvania;6. The Royal Marsden NHS Foundation Trust, London, United Kingdom;7. Statistics Department, EORTC Headquarters, Brussels, Belgium;8. Department of Pediatric Hematology and Oncology, University Hospital, Muenster, Germany;9. Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom;10. Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands;11. Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands;12. Cancer Medicine and Consultant Medical Oncologist, The London Sarcoma Service, University College Hospital, London, United Kingdom;13. Faculty of Pharmacy, University of Sydney, Sydney, Australia;14. Cancer Research UK, Cancer Trials Unit, University of Birmingham, Birmingham, United Kingdom;15. Departments of Biostatistics and Epidemiology, Gustave‐Roussy, Paris, France;16. Paris‐Saclay and Paris‐SudUniversities, Villejuif, France;17. Gustave Roussy, Ligue Nationale Contre le Cancer Meta‐analysis Platform, Villejuif, France;18. Radiation EpidemiologyGroup, INSERM, Villejuif, France
Abstract:
Keywords:acute toxicity  alkylating agent  cyclophosphamide  efficacy  ifosfamide  individual patient data  meta‐analysis  sarcoma  systematic review  treatment‐by sex interaction
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