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Interleukin‐8‐producing primary cardiac undifferentiated sarcoma in a child with sustained fever |
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| Authors: | Ryu Yanagisawa Tomohiko Nakamura Yoshifumi Ogiso Akira Hachiya Ikuko Fujihara Daisuke Morita Kazuo Sakashita Masatomo Kitamura Hikoro Matsui Fumie Nishijima Hidetaka Hayashi Eiko Hidaka Kenji Sano Masaaki Shiohara Satoshi Yasukochi |
| Affiliation: | 1. Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan;2. Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan;3. Life Science Research Center, Nagano Children's Hospital, Azumino, Japan;4. Division of Clinical Pathology, Nagano Children's Hospital, Azumino, Japan;5. Department of Pediatric Intensive Care, Nagano Children's Hospital, Azumino, Japan;6. Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan;7. Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan;8. Department of Pediatrics, Matsumoto Dental University School of Dentistry, Shiojiri, Japan;9. Division of Pediatric Cardiology, Nagano Children's Hospital, Azumino, Japan |
| Abstract: | We report the case of a 12‐year‐old boy with primary undifferentiated sarcoma of the left atrium. He had sustained fever during the clinical course and multiple lung and brain metastases. Chemotherapy and irradiation were ineffective; he died 41 days after hospitalization. On retrospective analysis, interleukin‐8 (IL‐8) was elevated; this was supported by immunohistochemistry and gene expression analysis of tumor samples. IL‐8 continued to increase with tumor progression accompanied by elevated neutrophil count and C‐reactive protein. IL‐8 is involved in malignant tumor proliferation, migration, and angiogenesis and may have been related to the clinical condition and prognosis in the present case. |
| Keywords: | interleukin‐8 left atrium metastasis primary cardiac tumor undifferentiated sarcoma |