Rotavirus‐associated hemophagocytic lymphohistiocytosis (HLH) after hematopoietic stem cell transplantation for familial HLH |
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| Authors: | Meerim Park Yeong Ju Yun Sung Il Woo Jae Wook Lee Nack‐Gyun Chung Bin Cho |
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| Affiliation: | 1. Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea;2. Department of Pediatrics, Seoul St Mary's Hospital, Catholic University of Korea, Seoul, Korea |
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| Abstract: | Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening disorder of immune regulation. HLH consists of two forms: familial and acquired, the latter which occurs in association with infection, malignancy, rheumatic disease and acquired immune deficiency. Herein, we report a case of acquired HLH in a child who had received allogeneic hematopoietic stem cell transplantation for familial HLH with UNC13D mutation. Based on microbiology, only rotavirus was identified as a possible organism triggering HLH. The patient's fulminant clinical course included acute respiratory failure, a sepsis‐like pattern, disseminated intravascular coagulopathy, and rhabdomyolysis, leading to multiorgan failure and death from septic shock. |
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| Keywords: | acquired familial hematopoietic stem cell transplantation hemophagocytic lymphohistiocytosis rotavirus |
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