Secondary neuroendocrine tumor after allogeneic bone marrow transplantation |
| |
| Authors: | Shinichi Tamura Hiroyuki Ishida Takeshi Naito Osamu Kondo Masami Inoue Keisei Kawa Kenji Kawabata Hiroshi Hojo Kazutaka Ouchi Toshihiko Imamura |
| |
| Affiliation: | 1. Department of PediatricsMatsushita Memorial Hospital;2. Department of PediatricsKyoto City Hospital;3. Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto;4. Department of Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka;5. Department of Pathology, Matsushita Memorial Hospital, Moriguchi;6. Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan |
| |
| Abstract: | Here we report a case of aggressive neuroendocrine tumor (NET), which is an extremely rare secondary solid tumor that occurs after allogeneic hematopoietic cell transplantation (allo‐HSCT). A patient with chronic active Epstein–Barr virus infection received allo‐HSCT from an HLA‐DR two allele‐mismatched unrelated donor. Four years later, he developed NET with multiple metastases. He received thoraco‐abdominal irradiation as a conditioning regimen, and developed repeated episodes of intestinal graft‐versus‐host disease, for which he received long‐term immunosuppressive therapy. Although these factors may be potential contributing factors to the development of secondary NET, the exact pathogenesis remains unclear. |
| |
| Keywords: | allogeneic hematopoietic stem cell transplantation chronic active Epstein– Barr virus infection neuroendocrine tumor secondary solid tumor |
|
|
