| 金黄地鼠高血脂模型的建立 |
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| 引用本文： | 郭金英,李华,谢人明. 金黄地鼠高血脂模型的建立[J]. 实验动物与比较医学, 2007, 27(1): 5-7 |
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| 作者姓名： | 郭金英 李华 谢人明 |
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| 作者单位： | 西北农林科技大学葡萄酒学院，西北农林科技大学葡萄酒学院，陕西省中医药研究院中药研究所 杨凌712100，河南科技大学食品与生物工程学院，洛阳471003，杨凌712100，西安710003 |
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| 摘 要： | 血压是动物实验中最常用的检测指标之一，为了得到可信的血压值，应尽可能采用直接的检测仪器，并避免仪器本身和动物所处环境的影响。遥感测量可在动物清醒并自由活动下持续监测血压而成为动物血压检测的首选方法。Schreuder等采用在大鼠植入遥测装置的方法，比较了6和12月龄雄性Wistar大鼠工作日（周五）和非工作日（周六，周日）的遥测血压数据。结果表明，工作日和非工作日雄性Wistar大鼠的心律、自发性运动、收缩压和舒张压指标存在相当大差异，分别达到2．2％（P〈0．001），32．9％（P〈0．05），3．2％（P〈0．05）和3．7％（P〈0．05），而6月龄和12月龄大鼠之间没有差异。这一现象对于解释动物实验结果有参考意义。[第一段]
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| 关 键 词： | Wistar大鼠 遥测装置 血压 雄性 动物实验 检测指标 检测仪器 6月龄 |
| 修稿时间： | 2006-01-05 |
Establishment of Golden Hamster Model of Hyperlipidemia |
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| GUO Jin-ying,LI Hu,XIE Ren-ming. Establishment of Golden Hamster Model of Hyperlipidemia[J]. Laboratory Animal and Comparative Medicine, 2007, 27(1): 5-7 |
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| Authors: | GUO Jin-ying LI Hu XIE Ren-ming |
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| Affiliation: | 1. Department of Pharmacology, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China; 2. Shanghai Fudan-zhangjiang Bio-Pharmaceutical Co.,Ltd, Shanghai 201203, China |
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| Abstract: | Objective To establish a golden hamster model of hyperlipidemia.Methods 20 golden hamsters were randomly divided into control and experimental groups,10 per each group.The hamsters of experimental group were treated with high cholesterol diet for 15 days.During the experiment,the gross health status was observed.Finally,the contents of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein-cholesterol(HDL-C),low-density lipoprotein-cholesterol(LDL-C) and very low-density lipoprotein-cholesterol(VLDL-C) were assayed,and pathological changes of the liver were examined by light and electron microscopy.Results The golden hamsters showed to be well toleranble to high cholesterol diet.After 15 days,the contents of serum TC, TG,HDL-C,LDL-C and VLDL-C were 9.06,4.19,2.43,6.21,18.88 fold-increased,respectively(P<0.01),but the ratio of HDL-C/(LDL-C VLDL-C) decreased significantly compared with that in the normal group(P<0.05).The pathological examination exhibited liver structural alterations.Conclusion It is a quite rapid and reliable way to establish hyperlipidemia model of golden hamster,which can continuously provide enough plasma for hyperlipidemia research. |
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| Keywords: | Golden hamster(Mesocricetus auratur) Hyperlipidemia Model |
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