| 133例男性原发不育患者染色体核型及Y染色体微缺失分析 |
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| 引用本文： | 纪妍,徐宏甲,黄健初. 133例男性原发不育患者染色体核型及Y染色体微缺失分析[J]. 南方医科大学学报, 2010, 30(2): 388 |
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| 作者姓名： | 纪妍 徐宏甲 黄健初 |
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| 作者单位： | 惠州市中心人民医院妇产科,广东,惠州,516000;东莞市计划生育服务中心,广东,东莞,523000 |
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| 摘 要： | 目的探讨染色体核型异常及Y染色体微缺失与男性原发不育的关系。方法利用染色体技术、PCR技术等对133例男性不育患者进行外周血染色体分析及Y染色体微缺失检测。结果133例男性原发不育患者中发现异常核型25例(18.80%);发现Y染色体微缺失12例(9.02%),其中2例精索静脉曲张及2例隐睾患者;4人同时存在染色体核型异常及Y染色体微缺失。结论男性原发不育与染色体核型异常及Y染色体微缺失关系密切,对男性原发不育患者进行染色体核型及Y染色体微缺失检测非常重要。
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| 关 键 词： | 不育症 染色体核型 Y染色体微缺失 精索静脉曲张 男性 |
Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients |
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| JI Yan,XU Hong-jia,HUANG Jian-chu. Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients[J]. Journal of Southern Medical University, 2010, 30(2): 388 |
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| Authors: | JI Yan XU Hong-jia HUANG Jian-chu |
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| Affiliation: | JI Yan1,XU Hong-jia2,HUANG Jian-chu2 1Department of Obstetrics , Gynecology,Huizhou Municipal Central Hospital,Huizhou 516000,China,2Dongguan Family Planning Service Center,Dongguan 52300 |
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| Abstract: | Objective To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients.Methods Karyotypic anlaysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis.Results Of the 133 patients,25(18.80%) were found to have chromosome abnormalities,and 12(9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism.Four patients ... |
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| Keywords: | infertility chromosome karyotype Y chromosome microdeletion varicocele male |
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