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CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
Authors:Carol Sheridan  Hiromitsu Kishimoto  Robyn K Fuchs  Sanjana Mehrotra  Poornima Bhat-Nakshatri  Charles H Turner  Robert Goulet Jr  Sunil Badve  Harikrishna Nakshatri
Affiliation:(1) Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;(2) Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;(3) Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;(4) Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;(5) Walther Cancer Institute, Indianapolis, IN, 46208, USA;(6) Orthopedics Research Labs, Indiana University School of Medicine, Indianapolis, IN, 46202, USA;(7) Department Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA
Abstract:

Introduction  

A subpopulation (CD44+/CD24-) of breast cancer cells has been reported to have stem/progenitor cell properties. The aim of this study was to investigate whether this subpopulation of cancer cells has the unique ability to invade, home, and proliferate at sites of metastasis.
Keywords:
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