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| 基于SEER数据库分析联合肝切除术对II期胆囊癌患者预后的影响 | |
| 引用本文： | 胡炳仁,叶陈涛,屠卓隆,蔡华杰,杨寿璋,杨盈楠,屠金夫. 基于SEER数据库分析联合肝切除术对II期胆囊癌患者预后的影响[J]. 肝胆胰外科杂志, 2021, 33(6): 331-335. DOI: 10.11952/j.issn.1007-1954.2021.06.003 |
| 作者姓名： | 胡炳仁 叶陈涛 屠卓隆 蔡华杰 杨寿璋 杨盈楠 屠金夫 |
| 作者单位： | 温州医科大学附属第一医院 肝胆胰外科,浙江 温州 325035 |
| 基金项目： | 浙江省医药卫生科技计划项目（2021RC089）；温州市基础性科研项目（Y2020042）。 |
| 摘 要： | 目的 拟应用大数据库样本探讨不同手术策略对II期胆囊癌患者预后影响是否有差异.方法 从美国SEER数据库筛选2004年1月1日至2015年12月31日间诊断的529例II期胆囊癌患者,按手术策略分为联合肝脏切除术组、非联合肝脏切除术组,通过Kaplan-Meier生存分析绘制生存曲线并计算中位生存时间,利用Cox风险回... |
| 关 键 词： | II期胆囊癌 胆囊癌外科治疗 肝切除术 SEER数据库 生存分析 |
| 收稿时间： | 2021-05-08 |
Prognostic impact of surgical treatment combined with hepatectomy on stage II gallbladder cancer: a SEER-based study |
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| HU Bing-ren,YE Chen-tao,TU Zhuo-long,CAI Hua-jie,YANG Shou-zhang,YANG Ying-nan,TU Jin-fu. Prognostic impact of surgical treatment combined with hepatectomy on stage II gallbladder cancer: a SEER-based study[J]. Journal of Hepatopancreatobiliary Surgery, 2021, 33(6): 331-335. DOI: 10.11952/j.issn.1007-1954.2021.06.003 | |
| Authors: | HU Bing-ren YE Chen-tao TU Zhuo-long CAI Hua-jie YANG Shou-zhang YANG Ying-nan TU Jin-fu |
| Affiliation: | Department of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China |
| Abstract: | Objective To discuss the prognostic impact of different surgical treatments on stage II gallbladder cancer (GBC) patients. Methods Patients diagnosed with stage II GBC between Jan. 1 2004 and Dec. 31 2015 were selected from the Surveillance, Epidemiology, and End Results (SEER) database and were divided into surgery combined with hepatectomy group and surgery without hepatectomy group. Survival curves and median survival time (MST) were analyzed by Kaplan-Meier method. Cox regression model was used to determine the risk factors. Results Patients with stage II GBC undergoing surgery combined with hepatectomy had a longer MST (113 months) than those without hepatectomy (79 months), but the difference was not statistical significant (P=0.165). In the COX regression model, age was an independent prognositic factor, but surgery was not a significant independent factor for overall survival (HR 0.733, 95%CI 0.471~1.141, P=0.169). ConclusionSurvival outcomes for patients with stage II GBC underwent surgery with hepatectomy are not significantly different from those without hepatectomy. Hepatectomy may not be essential for stage II GBC surgical treatment. |
| Keywords: | stage II gallbladder cancer surgical treatment on gallbladder cancer hepatectomy Surveillance Epidemiology and End Results (SEER) database survival analysis |
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