| 口腔鳞癌患者的全血功能状态与肿瘤复发风险的相关性研究 |
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| 引用本文： | 刘华,余华芳,赵洪伟. 口腔鳞癌患者的全血功能状态与肿瘤复发风险的相关性研究[J]. 华西口腔医学杂志, 2007, 25(5): 467-469 |
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| 作者姓名： | 刘华 余华芳 赵洪伟 |
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| 作者单位： | 贵阳医学院,生物化学与分子生物学教研室;贵阳医学院附属医院,口腔颌面外科,贵州,贵阳,550002;口腔生物医学工程教育部重点实验室,四川大学,四川,成都,610041 |
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| 摘 要： | 目的检测口腔鳞癌患者的出、凝血功能变化，为临床诊治和预后评估提供参考。方法选择65例健康人（对照组）和351例口腔鳞癌患者（试验组）为研究对象，试验组又分为原发组、颈淋巴转移组和复发组。采用BTS- 330四通道自动血凝仪检测健康人和患者的血浆凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）及纤维蛋白原（Fib），用SPSS 11.0软件包进行统计分析。结果对照组与试验组的血浆PT和APTT有统计学差异（P<0.05），而TT和Fib无统计学差异（P>0.05）。对照组血浆PT较颈淋巴转移组和复发组缩短（P<0.05）；APTT除在颈淋巴转移组和复发组间无统计学差异外，其余各组间均有统计学差异（P<0.05）。结论PT和APTT可能对口腔鳞癌患者的临床诊治和预后评估有重要价值。
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| 关 键 词： | 口腔癌 鳞状细胞癌 凝血 复发 |
| 文章编号： | 1000-1182（2007）05-0467-03 |
| 收稿时间： | 2007-10-25 |
| 修稿时间： | 2007-03-09 |
Study on the relationship between function of blood and tumor recurrence in oral squamous cell carcinomas |
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| LIU Hua,YU Hua-fang,ZHAO Hong-wei. Study on the relationship between function of blood and tumor recurrence in oral squamous cell carcinomas[J]. West China journal of stomatology, 2007, 25(5): 467-469 |
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| Authors: | LIU Hua YU Hua-fang ZHAO Hong-wei |
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| Affiliation: | 1. Dept. of Biochemistry and Molecular Biology, Guiyang Medical College, Guiyang 550002, China; 2. Dept. of Oral and Maxillofacial Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang 550002, China; 3. Key. Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China |
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| Abstract: | Objective To explore the coagulation indexes and offer a valuable reference for clinic therapy and prognosis in patients with oral squamous cell carcinomas(OSCCs). Methods The indexes of prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT) and fibrinogen(Fib) were detected by using auto-matic blood coagulation testing machine in 65 healthy people and 351 patients with OSCCs. All patients with OSCCs were divided into three groups included primary tumor, neck metastasis of lymph nodes and recurrence. The data were analysed by SPSS 11.0. Results The index of PT in patients with OSCCs was longer than that of healthy people. There was a significance between the control group and the group with the neck metastasis of lymph node or the recurrence group(P<0.01). The time of APTT was shortened. Except for the group with the neck metastasis of lymph node and the recurrence group the distinctive difference existed in other groups(P<0.05). There was no significance between two groups in the indexes of TT and Fib(P>0.05). Conclusion PT and APTT may be the useful indexes for clinic therapy and prognosis in patients with oral squamous cell carcinomas. |
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| Keywords: | oral carcinoma squamous cell carcinoma coagulation recurrence |
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