Effects of moderate‐ and high‐intensity chronic exercise on brain‐derived neurotrophic factor expression in fast and slow muscles |
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| Authors: | Alberto Jiménez‐Maldonado PhD Joel Cerna‐Cortés PhD Elena M. Castro‐Rodríguez PhD Sergio A. Montero PhD Jesús Muñiz PhD Alejandrina Rodríguez‐Hernández PhD Mónica Lemus PhD Elena Roces De Álvarez‐Buylla BSc |
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| Affiliation: | 1. Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, México;2. Facultad de Medicina, Universidad de Colima, Colima, México |
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| Abstract: | Introduction: Brain‐derived neurotrophic factor (BDNF) protein expression is sensitive to cellular activity. In the sedentary state, BDNF expression is affected by the muscle phenotype. Methods: Eighteen Wistar rats were divided into the following 3 groups: sedentary (S); moderate‐intensity training (MIT); and high‐intensity training (HIT). The training protocol lasted 8 weeks. Forty‐eight hours after training, total RNA and protein levels in the soleus and plantaris muscles were obtained. Results: In the plantaris, the BDNF protein level was lower in the HIT than in the S group (P < 0.05). A similar effect was found in the soleus (without significant difference). In the soleus, higher Bdnf mRNA levels were found in the HIT group (P < 0.001 vs. S and MIT groups). In the plantaris muscle, similar Bdnf mRNA levels were found in all groups. Conclusions: These results indicate that high‐intensity chronic exercise reduces BDNF protein level in fast muscles and increases Bdnf mRNA levels in slow muscles. Muscle Nerve 53: 446–451, 2016 |
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| Keywords: | BDNF expression brain‐derived neurotrophic factor chronic exercise gene skeletal muscle |
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