Synthesis of [2H7]indatraline |
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| Authors: | L. Allmendinger K. T. Wanner |
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| Affiliation: | Department of Pharmacy—Center for Drug Research, Ludwig‐Maximilians‐Universit?t München, München, Germany |
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| Abstract: | Deuterium‐labelled indatraline was synthesized in high efficiency employing a Friedel–Crafts alkylation of [2H6]benzene with (E)‐3‐(3,4‐dichlorophenyl)acrylic acid as a key step. The desired labelling of the final compound was ascertained in two ways, by incorporation of [2H6]benzene in the target molecule and additionally by deuterium transfer to the non‐deuterated aryl moiety of the Friedel–Crafts alkylation product from [2H6]benzene, the latter thus serving as reagent and solvent. |
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| Keywords: | depression deuterium‐labelled compounds Indatraline triple reuptake inhibitor Friedel– Crafts alkylation Friedel– Crafts acylation H/D exchange |
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