In vitro and in vivo activities of fluoroquinolones against Aeromonas hydrophila |
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| Authors: | Ko Wen-Chien Chiang Shyh-Ren Lee Hsin-Chun Tang Hung-Jen Wang Yin-Yi Chuang Yin-Ching |
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| Affiliation: | Department of Medicine, National Cheng Kung University Medical College, National Cheng Kung University Hospital, Tainan, Taiwan. |
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| Abstract: | Aeromonas hydrophila, an uncommon human pathogen, can cause invasive infections in immunocompromised individuals. As the fluoroquinolones have been shown to be active in vitro against mesophilic aeromonads and clinical experience with the use of fluoroquinolones to treat aeromonads infections is limited, the antimicrobial activities of five selected drugs (ciprofloxacin, gatifloxacin, levofloxacin, lomefloxacin, and moxifloxacin) against A. hydrophila were studied in vitro and in mice. The MICs of the fluoroquinolones (except lomefloxacin), cefotaxime, and minocycline for 90% of 64 clinical isolates of A. hydrophila tested by the agar dilution method were
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