| 尼莫地平在健康男性国人中药物代谢动力学变异性 |
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| 引用本文： | 刘晓东 谢 林 徐光奇 王 进 周云曙 刘国卿. 尼莫地平在健康男性国人中药物代谢动力学变异性[J]. 中国药理学与毒理学杂志, 1996, 10(1): 25-27 |
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| 作者姓名： | 刘晓东 谢 林 徐光奇 王 进 周云曙 刘国卿 |
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| 作者单位： | 中国药科大学药物代谢研究中心 |
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| 摘 要： | 对２６名健康男性国人ｐｏ６０ｍｇ尼莫地平普通片后药代动力学进行研究．Ｃｍａｘ，Ｔｍａｘ，ｔ１／２，ＭＲＴ和ＡＵＣ分别为６９±３４μｇ·Ｌ－１，１．１±０．３ｈ，２．２±０．６ｈ．３３±０９ｈ和１８６±７３μｇ·ｈ·Ｌ－１．ＡＵＣ和Ｃｍａｘ有较大的个体差异．对ＡＵＣ值作频数和机率图分析结果表明存在双态分布．提示尼莫地平药代动力学存在多态性．根据ＡＵＣ值大小，将受试者分成快代谢型和慢代谢型两类，结果显示受试者大多（２４／２６）属于快代谢型（ＡＵＣ＞３００μｇ·ｈ·Ｌ－１）．
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| 关 键 词： | 尼莫地平；药物代谢动力学；个体变异性；人 |
| 收稿时间： | 1995-03-04 |
Variability of nimodipine pharmacokinetics in healthy Chinese males |
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| LIU Xiao-Dong, XIE Lin, XU Guang-Qi, WANG Jin, ZHOU Yun-Chu, LIU Guo-Qing. Variability of nimodipine pharmacokinetics in healthy Chinese males[J]. Chinese Journal of Pharmacology and Toxicology, 1996, 10(1): 25-27 |
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| Authors: | LIU Xiao-Dong XIE Lin XU Guang-Qi WANG Jin ZHOU Yun-Chu LIU Guo-Qing |
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| Affiliation: | (Centre of Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009) |
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| Abstract: | The pharmacokinetics of nimodipine (Nim) tablet in 26 healthy Chinese males was studied after an oral dose of 60 mg. Pharmacokinetic parameters for Tmax, Cmax, t1/2, MRT and AUC were estimated as follows. Tmax 1.1±0.3 h, Cmax 69±34 μg·L-1, t1/2 2.2±0.6 h, MRT 3.3±0.9 h, and AUC 186±74 μg·h·L-1. There were large intersubject variabilities in both AUC and Cmax. When individual AUC values were cumulated and the frequency histogram and probit analysis were performed, a bimodal distribution was observed. The result indicated the hypothesis of the existence of a polymorphism concerning Nim disposition kinetics. The individuals were grouped as fast and slow metabolizers according to the AUC values. High frequency (24/26) of fast metabolizers was found (AUC>300 μg·L-1). |
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| Keywords: | nimodipine pharmacokinetics variability humans |
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