| 左氧氟沙星296例不良反应文献分析 |
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| 引用本文： | 王志宏,张伟伟,封宇飞. 左氧氟沙星296例不良反应文献分析[J]. 药物流行病学杂志, 2011, 0(8): 430-433 |
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| 作者姓名： | 王志宏 张伟伟 封宇飞 |
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| 作者单位： | 卫生部北京医院( 北京 100730);卫生部北京医院( 北京 100730);卫生部北京医院( 北京 100730) |
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| 摘 要： | 目的:探讨左氧氟沙星致不良反应发生的规律及特点,为临床合理用药提供参考。方法:通过中国知网(CNKI)的中国医院知识仓库(CHKD)期刊全文数据库及万方数据库检索到1999～2010年有关左氧氟沙星致不良反应的有效文献322篇,并按患者性别、年龄、原患疾病与过敏史、给药途径、累及器官或系统及临床表现等方面进行统计、分析。结果:收集左氧氟沙星所致不良反应296例,其中,248例(83.78%)通过静脉途径给药;不良反应以神经系统及全身性损害最多,有79例(26.35%);其发生时间最早的在用药1min内,最迟的在用药2个月后。结论:左氧氟沙星引起的不良反应临床表现复杂多样,其发生与多种因素有关,最严重的可能引起死亡,值得临床医师关注。
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| 关 键 词： | 左氧氟沙星 药品不良反应 文献分析 |
| 收稿时间： | 2011-01-16 |
| 修稿时间： | 2011-05-06 |
Literature Analysis of 296 Cases of Levofloxacin induced Adverse Drug Reactions |
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| Wang Zhihong,Zhang Weiwei and Feng Yufei. Literature Analysis of 296 Cases of Levofloxacin induced Adverse Drug Reactions[J]. Chinese Journal of Pharmacoepidemiology, 2011, 0(8): 430-433 |
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| Authors: | Wang Zhihong Zhang Weiwei Feng Yufei |
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| Affiliation: | Wang Zhihong,Zhang Weiwei,Feng Yufei Department of Pharmacy,Beijing Hospital,Ministry of Public Health,Beijing 100730,China |
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| Abstract: | Objective:To explore the regularity and characteristics of ADRs induced by levofloxacin.Method: Based on the CHKD and Wanfang database,a total of 322 literatures about levofloxacin-induced ADRs were collected and statistically analyzed in respect of patients' gender,age,case history,administration route and clinical manifestation.Result: 248 cases(86.78%) were given levofloxacin intravenously.79 cases(26.35%) presented damages in the nervous system or the whole body.The most immediate ADR occurred within 1 ... |
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| Keywords: | Levofloxacin Adverse drug reactions(ADR) Literature analysis |
| 本文献已被 CNKI 维普 等数据库收录！ |
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