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| 磷酸化Afadin在骨质疏松患者大肠癌组织的表达研究 | |
| 引用本文： | 梁春慧,桂林,卞红磊,于溯洋,程敏静. 磷酸化Afadin在骨质疏松患者大肠癌组织的表达研究[J]. 中华老年骨科与康复电子杂志, 2019, 5(3): 162-166. DOI: 10.3877/cma.j.issn.2096-0263.2019.007 |
| 作者姓名： | 梁春慧 桂林 卞红磊 于溯洋 程敏静 |
| 作者单位： | 1. 050051 石家庄，河北医科大学第三医院药剂科2. 050051 石家庄，河北医科大学第三医院肛肠一科 |
| 基金项目： | 河北省卫生厅指导项目(20170634) |
| 摘 要： | 目的检测磷酸化Afadin在伴有骨质疏松的大肠癌患者肿瘤组织中的表达水平，分析其与临床病理因素以及总生存率的相关性。 方法回顾性筛选了73例伴有骨质疏松的大肠癌患者，收集组织标本，利用免疫组化及蛋白免疫印迹的方法对肿瘤组织中磷酸化Afadin的表达水平进行检测，与配对的非肿瘤组织进行比较，根据免疫组化染色结果，将患者分为磷酸化Afadin高表达和低表达两组，与临床病理资料进行相关性分析，采用Log-rank检验比较两组患者的总生存率，采用Cox比例风险模型，进行总生存的多因素分析。 结果与配对的非肿瘤组织相比，伴有骨质疏松的大肠癌患者肿瘤组织中磷酸化Afadin的表达水平升高，并且磷酸化Afadin的表达水平与肿瘤的浸润深度、淋巴结转移状况、脉管浸润以及神经侵犯状况相关，磷酸化Afadin高表达患者的总生存率降低，磷酸化Afadin表达水平是影响死亡的独立风险因素。 结论伴有骨质疏松的大肠癌患者肿瘤组织中存在磷酸化Afadin高表达的现象，磷酸化Afadin的表达水平和肿瘤的进展和预后相关。 |
| 关 键 词： | 大肠肿瘤 骨质疏松症 Afadin 预后 |
| 收稿时间： | 2018-12-05 |
Expression and clinical significance of phosphorylated Afadin in colorectal cancer patients with osteoporosis |
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| Chunhui Liang,Lin Gui,Honglei Bian,Suyang Yu,Minjing Cheng. Expression and clinical significance of phosphorylated Afadin in colorectal cancer patients with osteoporosis[J]. Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition), 2019, 5(3): 162-166. DOI: 10.3877/cma.j.issn.2096-0263.2019.007 | |
| Authors: | Chunhui Liang Lin Gui Honglei Bian Suyang Yu Minjing Cheng |
| Affiliation: | 1. Pharmacy Department, the Third hospital of Hebei Medical University, 050051 Shijiazhuang, China2. Department 1 of Anorectal Surgery, the Third hospital of Hebei Medical University, 050051 Shijiazhuang, China |
| Abstract: | ObjectiveTo investigate the expression of phosphorylated Afadin (p-Afadin) and to assess its relationship with clinicopathological features and prognosis in colorectal cancer(CRC) patients with osteoporosis. MethodsThe expression of p-Afadin in specimens form 73 colorectal cancer patients with osteoporosis was examined by immunohistochemistry (IHC) staining and Western blot, the results were compared with clinicopathological features and overall survival. ResultsThe expression of p-Afadin was upregulated in CRC tissues, high expression of p-Afadin was closely associated with depth of tumor invasion, lymph node metastasis, vascular invasion and perineural invasion, patients with high expression of p-Afadin had shorter overall survival. ConclusionHigh expression of p-Afadin is associated with CRC progression and poor prognsis in colorectal cancer patients with osteoporosis. |
| Keywords: | Colorectal neoplasms Osteoporosis Afadin Prognosis |
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