| 磷酸肌酸对心脏瓣膜置换术患者心肌保护效果评价 |
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| 引用本文： | 徐鲁峰, 封瑞, 于嵩, 吕福斌, 高成杰. 磷酸肌酸对心脏瓣膜置换术患者心肌保护效果评价[J]. 中国公共卫生, 2014, 30(2): 235-236. DOI: 10.11847/zgggws2014-30-02-35 |
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| 作者姓名： | 徐鲁峰 封瑞 于嵩 吕福斌 高成杰 |
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| 作者单位： | 1.济南军区总医院麻醉科, 山东 济南 250031;2.中国医科大学;3.辽宁中医药大学解剖组胚教研室 |
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| 基金项目： | 国家自然科学基金（81203004） |
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| 摘 要： | 目的初步评价磷酸肌酸对心脏瓣膜置换术患者心肌的保护作用。方法选择心脏瓣膜置换术患者60例，分为对照组和磷酸肌酸预处理组，对照组使用St.Thomas心脏停搏液，磷酸肌酸预处理组于St.Thomas心脏停搏液中加入磷酸肌酸（10 mmo1/L），测定血浆心肌肌钙蛋白、肌酸激酶及肌酸激酶同工酶含量。结果磷酸肌酸预处理组和对照组比较，体外循环停转流后2 h，心肌肌钙蛋白含量和肌酸激酶含量均明显下降（均P<0.05）；体外循环停转流后12 h，心肌肌钙蛋白含量、肌酸激酶含量和肌酸激酶同工酶含量均明显下降（均P<0.05）。结论磷酸肌酸对体外循环下行心脏瓣膜置换术患者具有明显的心肌保护作用。
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| 关 键 词： | 磷酸肌酸 心脏瓣膜病 心肌保护 体外循环 |
| 收稿时间： | 2013-12-10 |
Protective effect of phosphocreatine on myocardial in patients with heart valve replacement surgery |
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| XU Lu-feng, FENG Rui, YU Song.et al, . Protective effect of phosphocreatine on myocardial in patients with heart valve replacement surgery[J]. Chinese Journal of Public Health, 2014, 30(2): 235-236. DOI: 10.11847/zgggws2014-30-02-35 |
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| Authors: | XU Lu-feng FENG Rui YU Song.et al |
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| Affiliation: | 1.Department of Anesthesiology, Ji'nan Military General Hospital, Ji'nan, Shandong Province 250031, China |
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| Abstract: | ObjectiveTo evaluate protective effect of phosphocreatine on myocardial in patients with heart valve replacement surgery.MethodsSixty patients undergoing heart valve replacement surgery were selected and divided randomly into two groups(30 patients in each group).The patients in control group were given St.Thomas cardioplegic solution and those in phosphocreatine-treated group received St.Thomas cardioplegic solution plus phosphocreatine(10 mmol/L).The levels of cardiac troponin-I(cTnI),craetine kinase(CK),and creatine kinase-MB fraction (ck-MB) were measured.ResultsThe serum levels of cTnI and CK were significantly lower in phosphocreatine-treated group than those in the control group 2 hours after the cardiopulmonary bypass operation(all P<0.05),and the levels of cTnI,CK and CK-MB were significantly lower in phosphocreatine-treated group than those in the control group 12 hours after cardiopulmonary bypass operation(all P<0.05).ConclusionPhosphocreatine has significant protective effect on myocardial in patients with heart valve replacement surgery. |
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| Keywords: | phosphocreatine valvular heart disease myocardial protection extracorporeal circulation |
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