| 姜黄素纳米剂型及在神经系统疾病中应用的研究进展 |
| |
| 引用本文： | 任婧张丹参. 姜黄素纳米剂型及在神经系统疾病中应用的研究进展[J]. 神经药理学报, 2017, 7(5): 45-51. DOI: 10.3969/j.issn.2095-1396.2017.05.008 |
| |
| 作者姓名： | 任婧张丹参 |
| |
| 作者单位： | 河北科技大学，石家庄，050018，中国 |
| |
| 基金项目： | 河北省自然科学基金项目(No.H2016208058,No.H2016208059)；河北省高等学校科学技术研究项目(No.ZD2016009). |
| |
| 摘 要： | 姜黄素是从姜科植物姜黄属姜黄、莪术、郁金等根茎中提取到的一种天然黄色小分子植物酸性多酚，是中药姜黄的主要活性成分。姜黄素具有抗氧化、抗炎，神经保护作用以及调节神经递质和细胞内信号传导途径等药理作用，还可以增强神经可塑性，增加神经再生，这些药理作用使得姜黄素在神经退行性疾病以及情绪障碍方面的疾病中发挥了重要作用，目前可以作为阿尔茨海默病、帕金森病、抑郁症、脑缺血再灌注损伤等中枢神经系统疾病的控制与治疗的药物；姜黄素还有抑制肿瘤细胞增殖作用、临床也可用于脑胶质瘤的治疗和预防，姜黄素具有较高有效性和安全性，毒副作用小。但姜黄素难溶于水，生物利用度低等问题限制了姜黄素在临床用药上的发展前景，可以通过改变姜黄素的给药方式和剂型来弥补这种缺点。目前姜黄素可以制备脂质体、纳米粒、微球、胶束、微乳等剂型来进行不同方式的给 药，用来改善其亲水性，提高生物利用度。
|
| 关 键 词： | 姜黄素 神经中枢 阿尔茨海默 纳米剂型 |
Research Progress of Curcumin in the Treatment of Nervous System Diseases |
| |
| REN Jing,ZHANG Dan-shen. Research Progress of Curcumin in the Treatment of Nervous System Diseases[J]. Journal of Hebei North University(Medical Edition), 2017, 7(5): 45-51. DOI: 10.3969/j.issn.2095-1396.2017.05.008 |
| |
| Authors: | REN Jing ZHANG Dan-shen |
| |
| Affiliation: | Hebei University of Science and Technology，Shijiazhuang，050018，China |
| |
| Abstract: | Curcumin is a natural yellow small-molecular plant acid polyphenol extracted from the roots of the genus curcuma turmeric，curcuma，and turmeric. It is the main active ingredient of traditional chinese medicine turmeric. Curcumin has anti-oxidant，antiinflammatory， neuroprotective effects and pharmacological effects such as regulation of neurotransmitters and intracellular signaling pathways. It also enhances neuroplasticity and increases nerve regeneration. These pharmacological effects make curcumin play an important role in neurodegenerative diseases and emotions. It may be used as a drug for the control and treatment of central nervous system diseases such as Alzheimer’s disease，Parkinson’s disease，depression，cerebral ischemia-reperfusion injury in future； curcumin also inhibits tumor cells. Proliferation and clinical use can also be used for the treatment and prevention of glioma. Curcumin has high efficacy and safety，and has little side effects. However，curcumin is difficult to dissolve in water，and low bioavailability limits the development prospect of curcumin in clinical use. It can be compensated by changing the administration mode and dosage form of curcumin. Currently，curcumin can prepare lipids. Dosages such as body，nanoparticle，microspheres，micelles，and microemulsions are administered in different ways to improve their hydrophilicity and improve bioavailability. |
| |
| Keywords: | curcumin nerve center Alzheimer’s disease nano-dosage |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《神经药理学报》浏览原始摘要信息 |
|
点击此处可从《神经药理学报》下载免费的PDF全文 |
