| 胰岛功能指标在胰岛素瘤与胰岛素自身免疫综合征中比较分析 |
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| 引用本文： | 乔丽丽1,2,何庆1,贾彦春3,陈荷叶1,贾红蔚1. 胰岛功能指标在胰岛素瘤与胰岛素自身免疫综合征中比较分析[J]. 天津医科大学学报, 2020, 0(3): 218-221,229 |
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| 作者姓名： | 乔丽丽1 2 何庆1 贾彦春3 陈荷叶1 贾红蔚1 |
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| 作者单位： | （1.天津医科大学总医院内分泌代谢科,天津 300052;2.河北大学附属医院内分泌科,保定071000;3.天津市南开区三潭医院内科,天津 300193） |
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| 摘 要： | 目的:比较分析不同胰岛功能指标在胰岛素瘤和胰岛素自身免疫综合征（IAS）中的诊断价值。方法:回顾性分析我院2005年1月-2019年3月明确诊断的胰岛素瘤和IAS病例,比较分析胰岛素（INS）、胰岛素释放指数（IRI）、胰岛素释放修正指数（修正IRI）、C肽、C肽释放指数（CPI）、C肽释放修正指数（修正CPI）、胰岛素/C肽在两组诊断价值以及低血糖发作时胰岛素与C肽相关性研究。结果:胰岛素瘤组24例,IAS组9例,各指标在胰岛素瘤组和IAS组中均有差异。IAS组INS、IRI、修正IRI、C肽、CPI、修正CPI、胰岛素/C肽都高于胰岛素瘤组（均P<0.01）。低血糖发作时,IAS组INS与C肽之间相关性不显著,在胰岛素瘤组中相关性为0.695（P<0.01）。结论:利用各胰岛功能指标在胰岛素瘤和IAS中的差异表达,有助于提高胰岛素瘤和IAS在临床中的鉴别诊断。
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| 关 键 词： | 胰岛素瘤 胰岛素自身免疫综合征 胰岛功能 胰岛素 C肽 |
Comparative analysis of islet function indices in insulinoma and insulin autoimmune syndrome |
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| QIAO Li-li,' target=_blank rel=external>,HE Qing,JIA Yan-chun,CHEN He-ye,JIA Hong-wei. Comparative analysis of islet function indices in insulinoma and insulin autoimmune syndrome[J]. Journal of Tianjin Medical University, 2020, 0(3): 218-221,229 |
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| Authors: | QIAO Li-li ' target=_blank rel=external> HE Qing JIA Yan-chun CHEN He-ye JIA Hong-wei |
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| Affiliation: | （1.Department of Endocrinology and Metabolism, General Hospital, Tianjin Medical University, Tianjin 300052, China; 2. Department of Endocrinology,Affiliated Hospital of Hebei University,Baoding 071000, China; 3.Department of Medicine, Santan Hospital, Nankai District, Tianjin 300193, China） |
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| Abstract: | Objective: To evaluate the diagnostic value of different islet function indices in insulinoma and insulin autoimmune syndrome（IAS）. Methods: The clinical date of patients with insulinoma and insulin autoimmune syndrome were retrospectively analyzed from January 2005 to March 2019. The diagnostic value of insulin (INS), insulin release index (IRI), amended IRI, C-peptide, CPI, amended CPI, insulin/C-peptide in insulinoma and IAS were compared and the relationship between insulin and C-peptide during hypoglycemia were compared. Results: There were 24 cases in insulinoma group and 9 cases in IAS group,each index had significant differences between the two groups. The data of two groups showed that the expression level of insulin, insulin release index, amended IRI, C-peptide, CPI, amended CPI, insulin/C-peptide of the IAS group were higher than those in the insulinoma group(all P<0.05). There was no significant correlation between INS and C-peptide in IAS group when hypoglycemia,and the correlation in insulinoma group was 0.695, P<0.01. Conclusion: The differential expression of various islet function indexes in insulinoma and IAS is helpful to improve the differential diagnosis of insulinoma and IAS. |
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| Keywords: | insulinoma insulin autoimmune syndrome islet function insulin C-peptide |
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