DNA polymorphism assay distinguishes isolates of Leishmania donovani that cause kala-azar from those that cause post-kala-azar dermal Leishmaniasis in humans |
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| Authors: | Sreenivas Gannavaram Raju B V Subba Singh Ruchi Selvapandiyan Angamuthu Duncan Robert Sarkar Dwijen Nakhasi Hira L Salotra Poonam |
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| Affiliation: | Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India. |
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| Abstract: | Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates. |
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