Role of phase variation of type 1 fimbriae in a uropathogenic Escherichia coli cystitis isolate during urinary tract infection |
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Authors: | Snyder Jennifer A Lloyd Amanda L Lockatell C Virginia Johnson David E Mobley Harry L T |
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Affiliation: | Department of Microbiology and Immunology, Baltimore, MD 21201, USA. |
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Abstract: | Type 1 fimbrial phase-locked mutants of uropathogenic Escherichia coli cystitis isolate F11 were used to assess the role of the invertible element during urinary tract infection. Compared to the wild type, the phase-locked off mutant was attenuated, and constitutive production of type 1 fimbriae by the phase-locked on mutant did not provide a competitive advantage. |
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