| 吉西他滨联合卡铂与吉西他滨联合顺铂治疗晚期非小细胞肺癌的比较 |
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| 引用本文： | 舒阳春,刘魁凤,莫贤毅,温宗秋,陆崇. 吉西他滨联合卡铂与吉西他滨联合顺铂治疗晚期非小细胞肺癌的比较[J]. 实用肿瘤学杂志, 2008, 22(2): 101-103 |
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| 作者姓名： | 舒阳春 刘魁凤 莫贤毅 温宗秋 陆崇 |
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| 作者单位： | 广东药学院附属第一医院肿瘤科,广州,510080 |
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| 摘 要： | 目的 观察比较健择联合卡铂(GC方案)与健择联合顺铂(GP方案)治疗晚期非小细胞肺癌(NSCLC)的疗效及毒副反应.方法 81例晚期NSCLC患者随机分成GC方案组(40例)和GP方案组(41例).每例至少治疗2周期.结果 GC和GP组的有效率分别为37.5%和41.5%(P>0.05).中位疾病进展期为4.8个月和5.1个月(P>0.05),中位生存期为8.8个月和9.0个月(P>0.05),1年生存率为40.0%和41.5%(P>0.05).不良反应为骨髓抑制,胃肠道反应,脱发和皮疹.Ⅲ+Ⅳ度白细胞及血小板下降,两组无显著性差异(P>0.05),恶心、呕吐在GP组较GC组表现更为显著(P<0.05).结论 GC方案与GP方案治疗晚期NSCLC疗效相近,GC方案有更好的耐受性,可能对老年,体力状况差患者更为适用.
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| 关 键 词： | 吉西他滨 顺铂 卡铂 非小细胞肺癌 化疗 |
| 文章编号： | 1002-3070(2008)02-0101-03 |
| 修稿时间： | 2007-12-18 |
Comparison of efficacy and toxicity between gemcitabine plus carboplatin and gemcitabine plus cisplatin in the treatment of advanced non-small-cell lung cance |
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| SHU Yangchun,LIU Kuifeng,MO Xianyi,WEN Zongqiu,LU Chong. Comparison of efficacy and toxicity between gemcitabine plus carboplatin and gemcitabine plus cisplatin in the treatment of advanced non-small-cell lung cance[J]. Journal of Practical Oncology, 2008, 22(2): 101-103 |
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| Authors: | SHU Yangchun LIU Kuifeng MO Xianyi WEN Zongqiu LU Chong |
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| Affiliation: | (Department of Medical Oncology, the First Affiliated Hospital of Guang Dong University of Pharmacy, Guangzhou, 510080) |
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| Abstract: | Objective To observe the efficacy and toxicity of gemcitabine plus carboplatin(GC)versus gemcitabine plus cisplatin(GP)in the treatment of advanced non-small-cell lung cancer(Nsclc).Methods Eighty-one patients were randomized into GC group(n=40)and GP group(n=41).Results The response rates in GC group and GP group were 37.5% and 41.5% respectively(P>0.05).The median time of progression were 4.8 months and 5.1 months respectively(P>0.05).The median survival time were 8.8 months and 9.0 months respectively(P>0.05).Toxicites include myelosuppression,digestive reaction.alopecia and rash.Digestive toxicity in GC group was less than that in GP group(P<0.01).Conclusion The efficacy of GP regimen is similar to that of GC regimen in advanced Nsclc patients;GC regimen,with better overall tolerability,ismore suitable for elder patients. |
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| Keywords: | Gemcitabine Cisplatin Carboplatin non-small-cell lung cancer Chemotherapy |
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