| 2010-2012年浙江省衢州市涂阳肺结核患者结核菌株耐药状况分析 |
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| 引用本文： | 郝晓刚,王炜,王小林,张德和,余旭良,封苏平. 2010-2012年浙江省衢州市涂阳肺结核患者结核菌株耐药状况分析[J]. 疾病监测, 2013, 28(6): 467-469. DOI: 10.3784/j.issn.1003-9961.2013.6.013 |
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| 作者姓名： | 郝晓刚 王炜 王小林 张德和 余旭良 封苏平 |
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| 作者单位： | 1. 衢州市疾病预防控制中心,浙江衢州,324000
2. 衢州市人民医院 |
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| 摘 要： | 目的 分析结核分枝杆菌的耐药情况与耐药谱,为制订结核病控制对策提供依据。 方法 对2010-2012年期间在浙江省衢州市各个结核病定点医院就诊新发和复治涂阳患者进行结核杆菌培养,鉴定为结核分枝杆菌的菌株采用比例法进行6种抗结核药物[异烟肼(H)、利福平(R)、乙胺丁醇(E)、链霉素(S)、左氧氟沙星(OFX)、卡那霉素(KM)]耐药性测试。 结果 入选1169株结核分枝杆菌中,总体耐药率为22.80%,总体耐多药率为5.13%,广泛耐多药率为0.43%;单耐药谱位于前3位的是异烟肼、链霉素、氧氟沙星,多耐药谱位于前3位的是INH+SM、INH+SM+OFX、RFP +OFX;耐多药谱位于前3位的是INH+RFP+S、INH+RFP+SM+OFX和INH+RFP。 结论 耐药结核病已对衢州市结核病控制造成较大威胁,相关部门必须采取针对性的措施控制耐药结核病的流行。
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| 关 键 词： | 耐药谱 结核分枝杆菌 结核病控制 |
| 收稿时间： | 2013-02-22 |
Drug resistance of Mycobacterium tuberculosis in smear positive pulmonary tuberculosis patients in Quzhou,Zhejiang, 2010-2012 |
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| Abstract: | Objective To understand the drug resistance of Mycobacterium tuberculosis in Quzhou and provide evidence for the control of tuberculosis (TB). Methods Mycobacterium tuberculosis strains were isolated from the samples of the TB patients receiving treatment in the hospitals in Quzhou from 2010 to 2012. The drug susceptibility of the isolated strains to 6 anti TB drugs [isoniazid (INH), rifampicin (RFP), ethambutal (E); streptomycin (SM), levofloxacin (OFX) and kanamycin (KM)] was tested. Results Among 1169 strains tested, the overall drug resistant rate was 22.80%, the overall multi drug resistant rate was 5.13% and the extensive drug resistant rate was 0.43%; The mono drug resistant pattern was INH.SM OFX, the poly drug resistant pattern was INH+SM, INH+SM+OFX, RFP+OFX and the multi drug resistant pattern was INH+RFP+SM, INH+RFP+SM+OFX and INH+RFP. Conclusion Drug resistance of Mycobacterium tuberculosis has posed great threat to the control of TB. It is important for the health department to take targeted measures to control the prevalence of drug-resistant TB. |
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| Keywords: | drug resistance Mycobacterium tuberculosis tuberculosis control |
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