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Symptomatic androgen deficiency develops only when both total and free testosterone decline in obese men who may have incident biochemical secondary hypogonadism: Prospective results from the EMAS
Authors:Giulia Rastrelli  Terence W. O'Neill  Tomas Ahern  György Bártfai  Felipe F. Casanueva  Gianni Forti  Brian Keevil  Aleksander Giwercman  Thang S. Han  Jolanta Slowikowska‐Hilczer  Michael E.J. Lean  Neil Pendleton  Margus Punab  Leen Antonio  Jos Tournoy  Dirk Vanderschueren  Mario Maggi  Ilpo T. Huhtaniemi  Frederick C.W. Wu  the EMAS study group
Affiliation:1. Sexual Medicine and Andrology Unit, Department of Experimental Clinical and Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy;2. Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester and NIHR Manchester Musculoskeletal Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK;3. Andrology Research Unit, Division of Endocrinology, Diabetes & Gastroenterology, Domain of Cardiovascular, Metabolic and Nutritional Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK;4. Department of Obstetrics, Gynaecology and Andrology, Albert Szent‐Gy?rgy Medical University, Szeged, Hungary;5. Department of Medicine, Santiago de Compostela UniversityComplejo Hospitalario Universitario de Santiago (CHUS);6. CIBER de Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Santiago de Compostela, Spain;7. Endocrine Unit, Department of Experimental Clinical and Biomedical Sciences “Mario Serio”, University of Florence, Florence, Italy;8. Department of Clinical Biochemistry, University Hospital of South Manchester, Wythenshawe, Manchester, UK;9. Reproductive Medicine Centre, Malm? University Hospital, University of Lund, Malm?, Sweden;10. Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, UK;11. Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland;12. Department of Human Nutrition, University of Glasgow, Glasgow, UK;13. Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre Hope Hospital, Salford, UK;14. Andrology Unit, United Laboratories of Tartu University Clinics, Tartu, Estonia;15. Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, Katholieke Universiteit Leuven, Leuven, Belgium;16. Gerontology and Geriatrics, Department of Chronic diseases, Metabolism and Ageing, Katholieke Universiteit Leuven, Leuven, Belgium;17. Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
Abstract:
Keywords:androgen deficiency  free testosterone  obesity  secondary hypogonadism  sex hormone–  binding globulin  sexual symptoms  total testosterone
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