STK Receptor Tyrosine Kinase Regulates Susceptibility to Infection with Listeria monocytogenes |
| |
| Authors: | Michael A. Lutz Francine Gervais Alan Bernstein Arthur L. Hattel Pamela H. Correll |
| |
| Affiliation: | Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3500, USA. |
| |
| Abstract: | We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria. |
| |
| Keywords: | |
|
|
