| 重症手足口病并发神经源性肺水肿危险因素的Meta分析 |
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| 引用本文： | 冯慧芬1,赵秋民2,朱光1. 重症手足口病并发神经源性肺水肿危险因素的Meta分析[J]. 现代预防医学, 2015, 0(21): 3975-3978 |
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| 作者姓名： | 冯慧芬1 赵秋民2 朱光1 |
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| 作者单位： | 1.郑州大学第五附属医院感染科，河南 郑州 450052；2.郑州大学学报编辑部，河南 郑州 450052 |
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| 摘 要： | 摘要:目的 探讨重症手足口病（HFMD）并发神经源性肺水肿（NPE）的主要危险因素，为其早期识别、及时治疗提供参考依据。方法 应用Meta分析对国内外1990-2014年关于重症HFMD并发NPE危险因素的研究文献进行综合分析，经异质性检验，分别采用固定效应模型和随机效应模型进行相对危险度（OR值）合并，计算其95%可信区间（95%CI），并进行敏感性分析及发表偏倚评估，筛选重症HFMD并发NPE的危险因素。结果 共纳入研究文献14篇，病例（重症HFMD并发NPE，NPE）568例，对照（重症HFMD）1321例。NPE危险因素的合并OR值及95%CI分别为:嗜睡3.12（1.94～5.00）、呕吐3.85（2.04～7.25）、肢体震颤8.12（2.33～28.33）、不典型皮疹5.44（3.35～8.84）、血压增高或降低7.56（3.25～17.57）、心动过速16.33（8.55～31.20）、毛细血管充盈时间（CRT＞5s）6.22（2.87～13.50）、呼吸节律改变19.10（4.74～76.90）、高血糖（≥8.30 mmol/L）8.25（4.26～15.95）。结论 皮疹不典型的重症HFMD 患儿出现嗜睡、呕吐、心动过速、毛细血管充盈时间延长、血压增高或降低、呼吸节律改变以及血糖增高是NPE发生的危险因素。
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| 关 键 词： | 关键词:重症手足口病 神经源性肺水肿 病例对照研究 Meta 分析 危险因素 |
Risk factors of neurogenic pulmonary edema on patients with severe hand-foot-mouth disease: A meta-analysis |
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| FENG Hui-fen,ZHAO Qiu-min,ZHU Guang. Risk factors of neurogenic pulmonary edema on patients with severe hand-foot-mouth disease: A meta-analysis[J]. Modern Preventive Medicine, 2015, 0(21): 3975-3978 |
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| Authors: | FENG Hui-fen ZHAO Qiu-min ZHU Guang |
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| Affiliation: | *Department of Infectious Diseases, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China |
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| Abstract: | Abstract: Objective To investigate the risk factors of neurogenic pulmonary edema (NPE) on patients with severe hand-foot-mouth disease (HFMD) and to provide evidence for the prevention and treatment of NPE. Methods Databases (from 1994 to 2014) of case-control studies on risk factors of NPE among patients with severe HFMD were collected. Meta-analysis was performed to analyze the data. We took fixed models and random models to calculate combined odds ratio (OR) and its 95% confidence interval (95%CI), then the sensitivity analysis was performed and the publish bias was evaluated. Results A total of 14 papers involving 568 cases (severe HFMD with NPE, NPE) and 1321 controls (severe HFMD) were included in the review. For categorical variables, pooled OR and 95%CI were as follows: withdrawnness and lethargy 3.12 (1.94-5.00), vomiting 3.85 (2.04-7.25), limbs tremor 8.12 (2.33-28.33), atypical rash 5.44 (3.35-8.84), hypertension or hypotension 7.56 (3.25-17.57), tachycardia 16.33 (8.55-31.20), capillary refill time (CRT＞5s) 6.22 (2.87-13.50), respiratory rhythm abnormality 19.10 (4.74-76.90), hyperglycaemia (≥8.30 mmol/L) 8.25 (4.26-15.95). Conclusion NPE risk factors for atypical rash of children are severe HFMD drowsiness, vomiting, tachycardia, capilary time prolonging, higher or lower blood pressure, breathing rhythm changes and increased blood sugar. |
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| Keywords: | Keywords: Severe Hand-foot-mouth Disease Neurogenic Pulmonary Edema Case-control Study Meta-analysis Risk Factors |
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