| 青海高原地区脑炎脑膜炎症候群的病原学分析 |
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| 引用本文： | 赵金华. 青海高原地区脑炎脑膜炎症候群的病原学分析[J]. 现代预防医学, 2015, 0(16): 2908-2910 |
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| 作者姓名： | 赵金华 |
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| 作者单位： | 青海省疾病预防控制中心，青海 西宁 810007 |
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| 摘 要： | 摘要:目的 了解高原地区青海省脑炎脑膜炎症候群病例病原种类及其流行特征，探讨脑炎脑膜炎症候群的病原谱构成情况。方法 2009年9月-2011年12月，在青海省妇女儿童医院和青海红十字医院两家哨点医院采集脑炎/脑膜炎患者的脑脊液、全血、鼻/咽拭子、粪便等标本，用Real-time PCR方法对乙脑病毒、肠道病毒等4种病毒核酸检测和肺炎链球菌、脑膜炎奈瑟球菌等8种细菌培养鉴定。结果 收集329例病例，295份脑脊液均做了细菌和病毒学检测，细菌检出22株阳性菌株，阳性率7.46%，分布在50～岁组和2～岁组；病毒检出阳性18份，阳性率6.10%，分布在5岁以下儿童。检出的细菌依次为金黄色葡萄球菌、结核杆菌、隐球菌和大肠杆菌、肺炎链球菌、脑膜炎奈瑟菌；病毒主要为肠道病毒，其次为腮腺炎病毒和单纯疱疹病毒。结论 提示青海地区脑炎/脑膜炎症候群病原谱以细菌为主，肠道病毒也不可忽视，5岁以下儿童及无疫苗预防的脑炎脑膜炎是防控的重点。。
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| 关 键 词： | 关键词:青海高原 传染病监测 脑炎/脑膜炎症候群 病原学 |
Etiology analysis for syndromes of encephalitis and meningitis in the plateau of Qinghai province |
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| ZHAO Jin-hua. Etiology analysis for syndromes of encephalitis and meningitis in the plateau of Qinghai province[J]. Modern Preventive Medicine, 2015, 0(16): 2908-2910 |
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| Authors: | ZHAO Jin-hua |
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| Affiliation: | Qinghai center for disease control and prevention, Xinning, Qinghai 810007, China |
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| Abstract: | Abstract: Objective The aim of this study was to understand pathogen types in Qinghai, pathogen spectrum composition and epidemiological characteristics of meningitis encephalitis syndrome cases in the plateau area. Methods From September 2009 to December 2011, encephalitis/meningitis cerebrospinal fluid, blood, nose/throat swab, stool samples were collected at Qinghai women's and children's hospital and Qinghai red cross hospital. Nucleic acid were detected by real-time PCR method for Japanese encephalitis virus, mumps virus, intestinal virus, herpes simplex virus and seven bacteria including Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis, Cryptococcus neoformans, Streptococcus pneumoniae, Haemophilus influenzae type B and Neisseria meningitidis. Results The samples of 295 cases were collected. The positive rate of bacteria of cerebrospinal fluid specimens was 7.46%, with the distribution in 50 years old group and 2 years old group. The positive rate of virus was 6.10%, with the distribution in children under 5 years old. The most positive bacteria was Staphylococcus aureus, mycobacterium tuberculosis, Escherichia coli, Cryptococcus, streptococcus pneumonia. The main viruses were enterovirus, mumps virus and herpes virus hominis. Conclusion The main pathogen of plateau meningitis syndrome was bacteria, but encephalitis/meningitis caused by virus also accounted for a certain proportion. The main prevention and control group was children under 5 years old. The proportion of encephalitis and meningitis by non-vaccine preventable pathogens should be paid more attention. |
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| Keywords: | Keywords: Plateau of Qinghai Contagion surveillance Symptom of encephalitis and meningitis Etiology |
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