| 信阳市病毒性乙型肝炎疫苗接种效果调查 |
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| 引用本文： | 胡宝文,洪玲,雷显英,葛永胜,陆飞,张育铁. 信阳市病毒性乙型肝炎疫苗接种效果调查[J]. 疾病监测, 2009, 24(7): 517-519. DOI: 10.3784/j.issn.1003-9961.2009.07.015 |
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| 作者姓名： | 胡宝文 洪玲 雷显英 葛永胜 陆飞 张育铁 |
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| 作者单位： | 河南省信阳市狮河区疾病预防控制中心,河南,信阳,464000;河南省信阳市狮河区疾病预防控制中心,河南,信阳,464000;河南省信阳市狮河区疾病预防控制中心,河南,信阳,464000;河南省信阳市狮河区疾病预防控制中心,河南,信阳,464000;河南省信阳市狮河区疾病预防控制中心,河南,信阳,464000;河南省信阳市狮河区疾病预防控制中心,河南,信阳,464000 |
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| 摘 要： | 目的了解河南省信阳市浉河区病毒性乙型肝炎（乙肝）疫苗纳入规划免疫后出生的儿童血清学状况,评价乙肝疫苗（HepB）接种效果。方法按照抽样方案要求,随机调查267名1~14儿童,并采集其血清进行乙肝病毒（HBV）表面抗原（HBsAg）、乙肝病毒表面抗体（抗-HBs）和乙肝病毒核心抗体（抗-HBc） 检测,对HBsAg阳性者再进行乙肝病毒e抗原(HBeAg)和乙肝病毒e抗体(抗-Hbe)的检测。结果信阳市浉河区1~14岁儿童HBsAg阳性率为2.25%,抗-HBs阳性率为89.14%,HBV感染率为28.84%,不同年龄组和性别差异均无统计学意义。结论信阳市浉河区通过14年HepB的接种,农村地区近90%的儿童产生了乙肝保护性抗体,可以有效阻断乙肝在儿童间的传播,但应提高新生儿HepB首针及时接种率,阻断母婴传播,降低乙肝感染率和流行率。
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| 关 键 词： | 乙型肝炎 乙肝疫苗 血清流行病学 |
| 收稿时间： | 2008-12-31 |
Investigation on the effect of hepatitis B vaccine in Xingang,Henan |
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| HU Bao-wen , HONG Ling , LEI Xian-ying , GE Yong-sheng , LU Fei , ZHANG Yu-tie. Investigation on the effect of hepatitis B vaccine in Xingang,Henan[J]. Disease Surveillance, 2009, 24(7): 517-519. DOI: 10.3784/j.issn.1003-9961.2009.07.015 |
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| Authors: | HU Bao-wen HONG Ling LEI Xian-ying GE Yong-sheng LU Fei ZHANG Yu-tie |
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| Affiliation: | 1.Shihe Distric Center for Disease Control and Prevention of Xinyang, Henan, Xinyang 464000, China |
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| Abstract: | Objective To survey the hepatitis B serological status of children after hepatitis B vaccine was included in immunization program in Shihe district of Xinyang and evaluate the effect of hepatitis B vaccination. Methods According to the sampling plan, 267 children aged 1 - 14 years old were selected randomly and blood samples were taken from them to detect HBsAg, anti-HBs and anti-HBc, and for HBsAg positive children, HBeAg and anti-HBe were detected. Results The positive rate of HBsAg of the children in Shihe District was 2.25%, the positive rate of anti- HBs was 89.14%, and the HBV infection rate was 28.84%. The difference for different age and gender groups had statistical significance. Conclusion After the implementation of hepatitis B immunization for 14 years in shihe District of Xinyang, about 90% of children in rural area developed antibody to hepatitis B, which could block the transmission of hepatitis B among children. The first dose of hepatitis B vaccine should be administrated to the newborn timely to block the perinatal transmission and reduce hepatitis B infection rata and prevalence rate. |
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| Keywords: | hepatitis B hepatitis B vaccine seroepidemiology |
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