Construction of an Actinobacillus pleuropneumoniae serotype 2 prototype live negative-marker vaccine |
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| Authors: | Tonpitak Walaiporn Baltes Nina Hennig-Pauka Isabel Gerlach Gerald F |
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| Affiliation: | Institut für Mikrobiologie und Tierseuchen, Tieraerztliche Hochschule Hannover, Germany. |
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| Abstract: | Deletions were introduced into the ureC and apxIIA genes of an Actinobacillus pleuropneumoniae serotype 2 strain by homologous recombination and counterselection. The double-mutant contains no foreign DNA, is highly attenuated, protects pigs from homologous challenge upon a single aerosol application, and facilitates the serological discrimination of immunized and infected herds. |
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