The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis |
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| Authors: | Zsolt Sandor Andras Dekany Dezsö Kelemen Timea Bencsik Robert Papp Lorand Bartho |
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| Affiliation: | 1. Department of Pharmacology and Pharmacotherapy, University Medical School of Pecs, Pecs, Hungary;2. Department of Surgery, University Medical School of Pecs, Pecs, Hungary;3. Department of Pharmacognosy, University Medical School of Pecs, Pecs, Hungary |
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| Abstract: | The contractile effect of AITC (300 μM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization. It is concluded that TRPA1 activation stimulates a cholinergic mechanism in a tetrodotoxin‐resistant manner. |
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